Levemopamil
Levemopamil is a calcium channel blocker and 5-HT2 receptor antagonist. Levemopamil exerts renoprotective effects against ischemic acute kidney injury. Levemopamil is applicable to research related to ischemic acute renal failure.
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- CAS No.: 101238-51-1
- Formule: C23H30N2
- Masse moléculaire:334.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (female, adult, 191-239 g, left unilateral renal artery occlusion for 1 hour followed by 6 hours of reperfusion/reflow)[1]
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Dosage:6 mg/kg/h
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Administration:i.v.; continuous infusion; from 1 hour before ischaemia until 6 hours after reflow
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Result:Significantly increased urine flow and maintained measurable endogenous creatinine clearance in the ischaemic left kidney at 2 and 6 h of reperfusion.
Largely preserved mitochondrial ATP synthesis and normal ADP/O ratio.
Slightly attenuated the rise in cortical mitochondrial calcium content.
Chemical Information
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CAS No. 101238-51-1
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Masse moléculaire 334.50
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Formule C23H30N2
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SMILES
CN(CCC1=CC=CC=C1)CCC[C@@](C#N)(C2=CC=CC=C2)C(C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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