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Cat. No.: HY-161707

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MMP2-IN-4

MMP2-IN-4 (compound 3h) is a potent MMP2 inhibitor. MMP2-IN-4 inhibits MMP2, MMP9 and MMP12 with IC₅₀s of 266.74, 402.75 and 1237.39 nM, respectively.

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CAS No.: 92535-43-8
Formule: C₁₉H₂₂N₂O₅S
Masse moléculaire:390.45

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

MMP2-IN-4 Chemical Structure

CAS No.: 92535-43-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

MMP2-IN-4 (compound 3h) is a potent MMP2 inhibitor. MMP2-IN-4 inhibits MMP2, MMP9 and MMP12 with IC₅₀s of 266.74, 402.75 and 1237.39 nM, respectively^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.57 μM Compound: 3h'	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 38843586]
ACHN	IC₅₀	17.15 μM Compound: 3h'	Antiproliferative activity against human ACHN cells incubated for 72 hrs by MTT assay Antiproliferative activity against human ACHN cells incubated for 72 hrs by MTT assay	[PMID: 38843586]
HEK293	IC₅₀	292.73 μM Compound: 3h'	Cytotoxicity against HEK293 cells incubated for 72 hrs by MTT assay Cytotoxicity against HEK293 cells incubated for 72 hrs by MTT assay	[PMID: 38843586]
HT-1080	IC₅₀	19.67 μM Compound: 3h'	Antiproliferative activity against human HT-1080 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-1080 cells incubated for 72 hrs by MTT assay	[PMID: 38843586]
K562	IC₅₀	1.99 μM Compound: 3h'	Antiproliferative activity against human K562 cells incubated for 72 hrs by PrestoBlue assay Antiproliferative activity against human K562 cells incubated for 72 hrs by PrestoBlue assay	[PMID: 38843586]
U-87MG ATCC	IC₅₀	17.53 μM Compound: 3h'	Antiproliferative activity against human U-87 MG cells incubated for 72 hrs by MTT assay Antiproliferative activity against human U-87 MG cells incubated for 72 hrs by MTT assay	[PMID: 38843586]

Chemical Information

CAS No. 92535-43-8
Masse moléculaire 390.45
Formule C₁₉H₂₂N₂O₅S
SMILES

CC1=CC=C(S(N[C@@H](C(O)=O)CCC(NCC2=CC=CC=C2)=O)(=O)=O)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Das S, et al. Derivatives of D(-) glutamine-based MMP-2 inhibitors as an effective remedy for the management of chronic myeloid leukemia-Part-I: Synthesis, biological screening and in silico binding interaction analysis. Eur J Med Chem. 2024 Aug 5;274:116563. [Content Brief]

Calculators

Calculateur de molarité

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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MMP2-IN-4

Voir tous les produits spécifiques à Isoform MMP

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

MMP2-IN-4 Related Classifications

HY-161707 Related Classifications