Nauclefine
Based on 1 Customer Validation
Nauclefine is an indole alkaloid isolated from Nauclea officinalis. Nauclefine acts as a PDE3A modulator to induce cancer cell apoptosis through a PDE3A-SLFN12-dependent death pathway.
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- Pureté : 99.65%
- CAS No.: 57103-51-2
- Formule: C18H13N3O
- Masse moléculaire:287.32
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Nauclefine (250?nM, 48 h) can inhibit the viability of HeLa cells and induce apoptosis, resulting in cell death dependent on PDE3A and SLFN12. Nauclefine can bind PDE3A, but does not inhibit its phosphodiesterase activity, can promote the interaction between PDE3A and SLFN12, and promote cell death by increasing the stability of SLFN12[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 57103-51-2
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Appearance Solid
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Masse moléculaire 287.32
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Formule C18H13N3O
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Color Yellow to orange
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SMILES
O=C1C2=C(C=C3C4=C(CCN13)C5=C(C=CC=C5)N4)C=CN=C2
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Structure Classification
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvant et solubilité
In Vitro:
DMSO : 20 mg/mL (69.61 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4804 mL | 17.4022 mL | 34.8044 mL | 87.0110 mL |
| 5 mM | 0.6961 mL | 3.4804 mL | 6.9609 mL | 17.4022 mL | |
| 10 mM | 0.3480 mL | 1.7402 mL | 3.4804 mL | 8.7011 mL | |
| 15 mM | 0.2320 mL | 1.1601 mL | 2.3203 mL | 5.8007 mL | |
| 20 mM | 0.1740 mL | 0.8701 mL | 1.7402 mL | 4.3505 mL | |
| 25 mM | 0.1392 mL | 0.6961 mL | 1.3922 mL | 3.4804 mL | |
| 30 mM | 0.1160 mL | 0.5801 mL | 1.1601 mL | 2.9004 mL | |
| 40 mM | 0.0870 mL | 0.4351 mL | 0.8701 mL | 2.1753 mL | |
| 50 mM | 0.0696 mL | 0.3480 mL | 0.6961 mL | 1.7402 mL | |
| 60 mM | 0.0580 mL | 0.2900 mL | 0.5801 mL | 1.4502 mL |
Nauclefine Related Classifications
HY-N10149 Related Classifications
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