PLSRTLSVAAK
PLSRTLSVAAK is a peptide substrate used for the detection of PKC phosphorylation activity, and can be applied to in vitro kinase activity assays of PKCδ.
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- CAS No.: 105802-83-3
- Formule: C50H91N15O15
- Masse moléculaire:1142.35
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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PKCδ |
PLSRTLSVAAK (0.4 μg/μl; 30 min at 30°C) incubation of membrane-bound PKC preparations from BALB/c mouse hippocampal slices results in measurable substrate phosphorylation, while identical incubation with preparations from C57BL/6N mouse hippocampal slices shows no detectable phosphorylation[1].
PLSRTLSVAAK kinase-active c-Abl activates GST-PKCδ, which then increases phosphorylation of the PLSRTLSVAAK peptide substrate by a mean fold-increase of ~5 relative to PKCδ alone[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 105802-83-3
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Masse moléculaire 1142.35
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Formule C50H91N15O15
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Sequence
Pro-Leu-Ser-Arg-Thr-Leu-Ser-Val-Ala-Ala-Lys
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Sequence Shortening
PLSRTLSVAAK
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Blank T, Nijholt I, Grammatopoulos D K, et al. Corticotropin-releasing factor receptors couple to multiple G-proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learning[J]. Journal of Neuroscience, 2003, 23(2): 700-707. [Content Brief]
[2]. Yuan Z M, Utsugisawa T, Ishiko T, et al. Activation of protein kinase C δ by the c-Abl tyrosine kinase in response to ionizing radiation[J]. Oncogene, 1998, 16 [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PLSRTLSVAAK Related Classifications
HY-P11877 Related Classifications
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