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Cat. No.: HY-14749

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Pyronaridine

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Pyronaridine is an orally active Mannich base anti-malarial agent. Pyronaridine is active against P. falciparum and Echinococcus granulosus infection.

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CAS No.: 74847-35-1
Formule: C₂₉H₃₂ClN₅O₂
Masse moléculaire:518.05

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Pyronaridine Chemical Structure

CAS No.: 74847-35-1

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Activité biologique
- Description
- Cellular Effect
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Publications (1)
Pureté et documentation
Références
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Activité biologique

Description

Pyronaridine is an orally active Mannich base anti-malarial agent. Pyronaridine is active against P. falciparum and Echinococcus granulosus infection^[1]^[2].

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Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	CC₅₀	3549.5 nM Compound: Pyronaridine	Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay	[PMID: 30537832]
HEK293	IC₅₀	0.00179 μM Compound: Pyronaridine	Cytotoxicity against HEK293 cells assessed as cell viability after 72 hrs by resazurin-based plate reader analysis Cytotoxicity against HEK293 cells assessed as cell viability after 72 hrs by resazurin-based plate reader analysis	[PMID: 26651537]
HEK293	IC₅₀	1.8 μM Compound: Pyronaridine	Growth inhibition of HEK293 cells after 72 hrs by PrestoBlue staining based fluorescence assay Growth inhibition of HEK293 cells after 72 hrs by PrestoBlue staining based fluorescence assay	[PMID: 28001067]
HEK293	IC₅₀	1.8 μM Compound: Pyronaridine	Cytotoxicity against HEK293 cells Cytotoxicity against HEK293 cells	[PMID: 32067457]
HEK293	IC₅₀	1.99 μM Compound: Pyronaridine	Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye-based fluorescence assay Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye-based fluorescence assay	[PMID: 30865443]
HEK293	IC₅₀	2.9 μM Compound: Pyronaridine	Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay	[PMID: 29236492]
HEK293	IC₅₀	5.2 μM Compound: Pyronaridine	Cytotoxicity against human HEK293 cells after 72 hrs by resazurin dye based fluorescence assay Cytotoxicity against human HEK293 cells after 72 hrs by resazurin dye based fluorescence assay	[PMID: 29969262]
HEK293	IC₅₀	5.22 μM Compound: Pyronaridine	Growth inhibition of HEK293 cells Growth inhibition of HEK293 cells	[PMID: 28400231]
HeLa	IC₅₀	0.82 μM Compound: Pyronaridine	Antiviral activity against Ebolavirus infected in human HeLa cells assessed as reduction in viral replication incubated for 48 hrs by luminescence based assay Antiviral activity against Ebolavirus infected in human HeLa cells assessed as reduction in viral replication incubated for 48 hrs by luminescence based assay	[PMID: 32832035]
HeLa	IC₅₀	3.1 μM Compound: Pyronaridine	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by CellTiter Glo assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by CellTiter Glo assay	[PMID: 36208544]
HepG2	IC₅₀	<1 μM Compound: Pyronaridine	Antimalarial activity against sporozoite stage of Plasmodium yoelii assessed as invasion of human HepG2 cells expressing CD81 incubated for 2 hrs prior to inoculation measured after 1 hr by immunofluorescence assay in presence of penicillin/streptomycin Antimalarial activity against sporozoite stage of Plasmodium yoelii assessed as invasion of human HepG2 cells expressing CD81 incubated for 2 hrs prior to inoculation measured after 1 hr by immunofluorescence assay in presence of penicillin/streptomycin	[PMID: 23927658]
HT-1080	IC₅₀	4.23 μM Compound: Pyronaridine	Anticancer activity against human HT-1080 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based fluorescence assay Anticancer activity against human HT-1080 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based fluorescence assay	[PMID: 36208544]
Jurkat	IC₅₀	4 μM Compound: (4) Pyronaridine	Concentration required to reduce growth of human jurkat leukemia cells to 50% of control cultures, determined using a 72 hr continuous exposure Concentration required to reduce growth of human jurkat leukemia cells to 50% of control cultures, determined using a 72 hr continuous exposure	[PMID: 8182707]
SH-SY5Y	IC₅₀	1.7 μM Compound: Pyronaridine	Anticancer activity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based fluorescence assay Anticancer activity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based fluorescence assay	[PMID: 36208544]
SK-N-AS	IC₅₀	3.45 μM Compound: Pyronaridine	Anticancer activity against human SK-N-AS cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based fluorescence assay Anticancer activity against human SK-N-AS cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based fluorescence assay	[PMID: 36208544]
Vero 76	IC₅₀	1.3 μM Compound: Pyronaridine	Cytotoxicity against African green monkey Vero 76 cells assessed as reduction in cell viability Cytotoxicity against African green monkey Vero 76 cells assessed as reduction in cell viability	[PMID: 36208544]

In Vitro

Pyronaridine (24 h) shows anti-P. falciparum activity with an IC₅₀ value of 1.53-3.94 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pyronaridine (57 mg/kg, oral administration, q.d. for 30 days) reduces the parasitic burden in the Echinococcus granulosus-infected mice^[2].
Pyronaridine (57 mg/kg, intraperitoneal injection, q.d. for 3 days) reduces the parasitic burden in secondarily infected (cysts) mice^[2].
Pyronaridine (57 mg/kg, intraperitoneal injection, for a single dose) exhibits a higher exposure in the liver than in the plasma in male ICR mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Echinococcus granulosus-infected mice model^[2]
Dosage:

57 mg/kg
Administration:

Oral administration, q.d. for 30 days
Result:

Reduced 42.4% of parasite wet weight and killed 90.7% of secondary infection (cysts) of E. granulosus ss.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 74847-35-1
Masse moléculaire 518.05
Formule C₂₉H₃₂ClN₅O₂
SMILES

OC1=C(CN2CCCC2)C=C(NC3=C4N=C(OC)C=CC4=NC5=CC(Cl)=CC=C53)C=C1CN6CCCC6
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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mBio

Pyronaridine tetraphosphate is an efficacious antiviral and anti-inflammatory active against multiple highly pathogenic coronaviruses. [Abstract]

2023 Oct 31;14(5):e0158723. PMID: 37581442

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Vivas L, et al. Anti-malarial efficacy of pyronaridine and artesunate in combination in vitro and in vivo. Acta Trop. 2008 Mar;105(3):222-8. [Content Brief]

[2]. Jun Li, et al. Old drug repurposing for neglected disease: Pyronaridine as a promising candidate for the treatment of Echinococcus granulosus infections. EBioMedicine. 2020 Apr;54:102711. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Pyronaridine

1 Cited Publications

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Activité biologique
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Publications (1)
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Pyronaridine

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Pyronaridine

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Pyronaridine Related Classifications

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