SH543
SH543 is a potent anti-osteoporosis agent. SH543 inhibits nuclear factor κB ligand (RANKL)-induced osteoclastogenesis with an IC50 of 3.3 nM. SH543 directly binds to KEAP1, activates the Nrf2-HO-1 antioxidant pathway, reduces ROS levels, and inhibits PI3K-AKT and MAPK signaling pathways. SH543 attenuates pathological bone loss in ovariectomized mice. SH543 can be used for osteoporosis research.
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- Formule: C37H53NO2
- Masse moléculaire:543.82
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Chemical Information
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Masse moléculaire 543.82
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Formule C37H53NO2
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SMILES
C[C@]12[C@]([H])(C(C)(C3=C(C2)C=C4C=CC=CC4=N3)C)CC[C@@]5([C@@]1(C[C@H]([C@]6([C@]5(CC[C@@H]6[C@@]7(CC[C@@H](O7)C(C)C)C)C)[H])O)[H])C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SH543 Related Classifications
HY-180112 Related Classifications
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