Copy Link Print Information

Sunitinib glucuronate

(Synonyms: SU 11248 glucuronate)
108 Cited Publications
Avis client

Based on 108 publication(s) in Google Scholar

Sunitinib (SU 11248) glucuronate is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively. Sunitinib glucuronate, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

  • Pureté: 95.0%
  • CAS No.: 1818285-48-1
  • Formule: C28H37FN4O9
  • Masse moléculaire:592.61
  • Stockage:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Sunitinib glucuronate Chemical Structure
    Sunitinib glucuronate Chemical Structure
  • Experimental Validation Results for Sunitinib glucuronate
  • Experimental Validation Results for Sunitinib glucuronate
  • Experimental Validation Results for Sunitinib glucuronate
  • Experimental Validation Results for Sunitinib glucuronate
  • Experimental Validation Results for Sunitinib glucuronate
  • Experimental Validation Results for Sunitinib glucuronate
  • Experimental Validation Results for Sunitinib glucuronate
  • Experimental Validation Results for Sunitinib glucuronate
  • Experimental Validation Results for Sunitinib glucuronate
  • Experimental Validation Results for Sunitinib glucuronate
  • Experimental Validation Results for Sunitinib glucuronate
  • Experimental Validation Results for Sunitinib glucuronate
CAS No.: 1818285-48-1
Size
Prix
Stock
Quantité
Amount: USD 0.00
Please select quantity
or
or

* Veuillez sélectionner la quantité avant d'ajouter des articles.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of Sunitinib glucuronate:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
  • Activité biologique
  • Chemical Information
  • Pureté et documentation
  • Références
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) Sunitinib glucuronate

More
Customer Validation & Images
WBRT-PCRIHCCell Proliferation/Viability AssayIF
  • Cell Proliferation/Viability Assay
  • IF
  • WB
  • WB
  • WB
  • IHC
  • WB
  • WB
  • WB
  • WB
  • WB
  • RT-PCR

Voir tous les produits spécifiques à Isoform PDGFR

More

Voir tous les produits spécifiques à Isoform VEGFR

More
Keywords
MOQ
Minimum order quantity
100 mg

Obtenir un devis En stock

Other size
Obtenir un devis
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Enregistrer
Sign in to MedChemExpress
Enregistrer un nouveau compte

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • Sunitinib glucuronate Chemical Structure
    Sunitinib glucuronate Chemical Structure
    1/16
  • 1/16

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2023 May;13(5):514-522. [Abstract]

    Customer Validation
     Sunitinib (0-100 μM; 72 h) induces significant cell death in T98G cells.

  • 1/16

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2023 May;13(5):514-522. [Abstract]

    Customer Validation
     Sunitinib (3 μM; 24 h) increases the expression of γ-H2Ax and Temozolomide (TMZ; 10 μM; 24 h) increases the induction of Sunitinib, in T98G cells.

  • 1/16

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2023 May;13(5):514-522. [Abstract]

    Customer Validation
     Sunitinib (3 μM; 24 h) increases the expression of γ-H2Ax and Temozolomide (TMZ; 10 μM; 24 h) increases the induction of Sunitinib, in T98G cells.

  • 1/16

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: Theranostics. 2018 Jul 30;8(15):4262-4278. [Abstract]

    Customer Validation
     BV2 cells are pretreated with 0.1% DMSO (Ctrl), JuA (25 µM) or JuA (25 µM) with the indicated antagonist of RTKs (Dovitinib at 1 µM, Gefinitib at 2.5 µM, Sunitinib at 2.5 µM and LDC1267 at 1 µM) for 30 min, followed by administration of Aβ42 (5 μM) for 12 h.

  • 1/16

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2018 Nov:37:344-355. [Abstract]

    Customer Validation
     Sutent (Sunitinib Malate) treatment decreases lipid accumulation in adipose and liver tissues and increases UCP1 expression in brown adipose tissue. Western blot analysis of UCP1 protein expression level in mouse brown adipose.

  • 1/16

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2018 Nov:37:344-355. [Abstract]

    Customer Validation
     Sutent (Sunitinib Malate) treatment decreases lipid accumulation in adipose and liver tissues and increases UCP1 expression in brown adipose tissue. Representative images of immunohistochemistry stainining of UCP1 in BAT.

  • 1/16

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Nov 15;8(67):111110-111118. [Abstract]

    Customer Validation
     In cell EC50 determination of CHMFL-KIT-031 with parental Colo320DM (KIT wt) and KIT V559D overexpressed Colo320DM cells.

  • 1/16

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Jul 27;8(56):95116-95134. [Abstract]

    Customer Validation
     Abemaciclib causes increased PARP cleavage in RCC. In 786-O cells Abemaciclib exposure results in increased PARP cleavage. This effect is more rapid and pronounced when Abemaciclib is combined with Sunitinib.

  • 1/16

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Jul 27;8(56):95116-95134. [Abstract]

    Customer Validation
     Abemaciclib causes increased PARP cleavage in RCC. In Caki-1 cells Abemaciclib exposure results in increased PARP cleavage. This effect is more rapid and pronounced when Abemaciclib is combined with Sunitinib.

  • 1/16

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: J Med Chem. 2016 Sep 22;59(18):8456-72. [Abstract]

    Customer Validation
     Effect of compounds 1 (Imatinib), 2 (Sunitinib), and 35 on cKIT mediated signaling pathways in GIST-T1 and GIST-5R cancer cell lines.

  • 1/16

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: Int J Clin Exp Pathol. 2015 Apr 1;8(4):3871-81. [Abstract]

    Customer Validation
     The relationship between SOX9 and Raf/MEK/ERK signaling pathway. Co-treatment of si-SOX9-1 and Sorafenib (10uM, 15uM)/Sunitinib (2 uM, 3 uM) significantly decreases expression of MEK1 and its phosphorylated protein (p-MEK1/2, p-ERK1/2) as assayed by Western blot (with GAPDH as internal control).

  • 1/16

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: Int J Clin Exp Pathol. 2015 Apr 1;8(4):3871-81. [Abstract]

    Customer Validation
     The relationship between SOX9 and Raf/MEK/ERK signaling pathway. Co-treatment of si-SOX9-1 and Sorafenib (10uM, 15uM)/Sunitinib (2 uM, 3 uM) significantly decreases expression of MEK1 and its phosphorylated protein (p-MEK1/2, p-ERK1/2) as assayed by RT-PCR (with β-actin as internal control).

  • Sunitinib glucuronate