TB22
TB22 is a non-nucleoside inhibitor of DOT1LR231Q, possessing anticancer activity. TB22 inhibits the malignant phenotype of lung cancer cells carrying the R231Q mutation through the MAPK/ERK signaling pathway, and can be used for lung cancer research.
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- Formule: C32H46ClN7O3S
- Masse moléculaire:644.27
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Voir tous les produits spécifiques à Isoform Histone Methyltransferase
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H460 | IC50 |
19.97 μM
Compound: TB22
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Antiproliferative activity against human NCI-H460 cells harboring wildtype DOT1L (unknown origin) (1 to 416 residues) assessed as inhibition of cell proliferation incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human NCI-H460 cells harboring wildtype DOT1L (unknown origin) (1 to 416 residues) assessed as inhibition of cell proliferation incubated for 72 hrs by CCK-8 assay
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[PMID: 39255403] |
| NCI-H460 | IC50 |
2.85 μM
Compound: TB22
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Antiproliferative activity against human NCI-H460 cells harboring DOT1L R231Q mutant (unknown origin) (1 to 416 residues) assessed as inhibition of cell proliferation incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human NCI-H460 cells harboring DOT1L R231Q mutant (unknown origin) (1 to 416 residues) assessed as inhibition of cell proliferation incubated for 72 hrs by CCK-8 assay
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[PMID: 39255403] |
Chemical Information
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Masse moléculaire 644.27
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Formule C32H46ClN7O3S
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SMILES
CC(C1=CC=C(C=C1)NC(NCCCN(CCCN2CCOCC2)CC3(O)CN(CC3)C4=NC(Cl)=NC5=C4C=CS5)=O)(C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TB22 Related Classifications
HY-162939 Related Classifications
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