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VVZ-068

VVZ-068 is a benzamide derivative and also a GlyT2/5HT2A antagonist. VVZ-068 alleviates neuropathic mechanical hyperalgesia in a rat model of mechanical allodynia. VVZ-068 is applicable for pain-related research.

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CAS No.: 1440797-80-7
Formule: C₂₀H₃₂N₂O₅
Masse moléculaire:380.48

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Please store the product under the recommended conditions in the Certificate of Analysis.

VVZ-068 Chemical Structure

CAS No.: 1440797-80-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

GlyT2

5-HT_2A Receptor

Voir tous les produits spécifiques à Isoform GlyT :

GlyT1
GlyT2

Voir tous les produits spécifiques à Isoform 5-HT Receptor :

In Vitro

VVZ-068 (10 μM) inhibits GlyT2 in 293T cells stably expressing rat GlyT2, and inhibits 5HT2A in 293T cells expressing human 5HT2A^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VVZ-068 (50-100 mg/kg, s.c./p.o., single administration) significantly increases the paw withdrawal threshold in rats with mechanical allodynia induced by L5/L6 spinal nerve ligation, and rapidly alleviates neuropathic mechanical hyperalgesia^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male SD rats, 100-120 g^[1]
Dosage:

50 (s.c.), 100 (p.o.) mg/kg
Administration:

s.c./p.o., single administration
Result:

Significantly increased the paw withdrawal threshold in rats with mechanical allodynia induced by L5/L6 spinal nerve ligation, and rapidly alleviated neuropathic mechanical hyperalgesia.

Chemical Information

CAS No. 1440797-80-7
Masse moléculaire 380.48
Formule C₂₀H₃₂N₂O₅
SMILES

O=C(C1=CC(OC)=C(C(OC)=C1)OCCCC)NCC2(CCOCC2)NC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Lee Du-hyeon, et al. Novel benzamide derivative and use thereof. WO2013081400A2. 2014-05-29

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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VVZ-068

Voir tous les produits spécifiques à Isoform GlyT

Voir tous les produits spécifiques à Isoform 5-HT Receptor