Y02224
Y02224 is a potent BRD4 inhibitor and exhibits reasonable antiproliferative effect on leukemia cells.Y02224 has the potential for? CRPC research.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1853988-48-3
- Formule: C20H17BrN2O4S
- Masse moléculaire:461.33
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
IC50 & Target
IC50: BRD4[1]
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
2.99 μM
Compound: 85
|
Antiproliferative activity against human HL60 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human HL60 cells after 72 hrs by CCK8 assay
|
[PMID: 26731490] |
| HT-29 | IC50 |
12.9 μM
Compound: 85
|
Antiproliferative activity against human HT-29 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human HT-29 cells after 72 hrs by CCK8 assay
|
[PMID: 26731490] |
| MV4-11 | IC50 |
1.3 μM
Compound: 85
|
Antiproliferative activity against human MV4-11 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human MV4-11 cells after 72 hrs by CCK8 assay
|
[PMID: 26731490] |
Chemical Information
-
CAS No. 1853988-48-3
-
Masse moléculaire 461.33
-
Formule C20H17BrN2O4S
-
SMILES
O=C1C2=C(C3=CC=C2)C(N1CC)=CC=C3NS(C4=C(C=CC(Br)=C4)OC)(=O)=O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
-
Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Y02224 Related Classifications
HY-114902 Related Classifications
Powered by Bioz