YK-8S
YK-8S is a dual-targeted K-Ras (G12D/G12C) covalent inhibitor. YK-8S shows no significant binding to wild-type K-Ras and other mutants (G12R, G13D, Q61R/K). YK-8S exhibits anti-proliferative activity against H358 (G12C) and AGS (G12D) cells. YK-8S inhibits the phosphorylation of p-AKT/p-ERK in BaF3/G12D and G12C cells. YK-8S can be used for pancreatic cancer, colorectal cancer and other tumors with high incidence of G12D.
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- CAS No.: 3060515-08-1
- Formule: C34H31F3N6O3
- Masse moléculaire:628.64
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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KRas G12D |
KRas G12C |
Akt |
ERK |
Chemical Information
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CAS No. 3060515-08-1
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Appearance Solid
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Masse moléculaire 628.64
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Formule C34H31F3N6O3
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SMILES
FC1=C(C2=C(C=C1)C=CC=C2C3=C(C4=C(C=N3)C(N5CCN(CC5)C([C@H]6OC6)=O)=NC(OC[C@]78C[C@H](CN7CCC8)F)=N4)F)C#C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (272 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
YK-8S Related Classifications
HY-159591 Related Classifications
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