CDK2-IN-61
CDK2-IN-61 is a highly selective CDK2 inhibitor with a human IC50 of 0.25 nM. CDK2-IN-61 can be used in cancer-related research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 2498658-20-9
- Formel: C21H25N5O4S
- Molecular Weight:443.52
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
CDK2/cyclinE 0.25 nM (IC50) |
In Vitro
CDK2-IN-61 (compound 4g) exhibits inhibitory activity against CDK2/cyclin E1 with an IC50 value of 0.25 nM, and shows 1200-fold, 1000-fold, and 230-fold selectivity over CDK1/cyclin B1, CDK4/cyclin D1, and CDK6/cyclin D1, respectively[1].
CDK2-IN-61 exhibits a potency of 670 nM in in vitro human whole blood assays; it shows excellent kinome-wide selectivity in a cell-free kinome screening panel containing 54 kinases; and it displays a clearance rate of 0.8 L/h/kg in cell-free human liver microsome assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
-
CAS. Nr. 2498658-20-9
-
Molecular Weight 443.52
-
Formel C21H25N5O4S
-
SMILES
O=C1C2(CC2)C3=CN=C(NC4=CC=C(C=C4)S(NC)(=O)=O)N=C3N1[C@H]5C[C@@H](CCC5)O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CDK2-IN-61 Related Classifications
HY-184884 Related Classifications
Powered by Bioz