Art. -Nr.: HY-W275882

1,6-Dimethoxyhexane

Name: 1,6-Dimethoxyhexane
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SKU: HY-W275882
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1,6-Dimethoxyhexane is an aliphatic ether that serves as a PROTAC linker and fuel additive. 1,6-Dimethoxyhexane is an orally active testicular toxicant. It has no direct toxicity on its own, but exerts toxicity after oxidative metabolism by liver/testicular microsomes to produce 2-Methoxyacetic Acid (MAA). 1,6-Dimethoxyhexane induces apoptosis/necrosis of pachytene spermatocytes, downregulates the expression of HSP70.2, HSP60 and ERp60/PDI A3, and causes spermatogenic tubule degeneration, testicular/thymic atrophy, a sharp decline in epididymal sperm density, and other effects. 1,6-Dimethoxyhexane can be used in studies related to testicular toxicity.

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CAS. Nr.: 13179-98-1
Formel: C₈H₁₈O₂
Molecular Weight:146.23

Speicherung:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

1,6-Dimethoxyhexane Chemical Structure

CAS. Nr.: 13179-98-1

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

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In Vivo

Endoplasmic Reticulum StressMitochondrial FunctionOxidative StressRenal Regulation

Endoplasmic Reticulum Stress

Mitochondrial Function

1,6-Dimethoxyhexane (200 mg/kg; p.o.; 5 days per week; 4 weeks) induces testicular toxicity in male Sprague-Dawley rats, characterized by significant downregulation of HSP70.2, HSP60, and ERp60 proteins, plus other differentially expressed testis proteins^[1].

Oxidative Stress

Renal Regulation

1,6-Dimethoxyhexane (200 mg/kg; p.o.; 5 days per week; 4 weeks) induces significant testicular toxicity and thymic toxicity, alongside adaptive hepatic, thyroid, and bone marrow changes, with elevated plasma and urinary MAA levels correlating with toxic severity in male Sprague-Dawley rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (7-week-old male)^[1]
Dosage:

200 mg/kg
Administration:

p.o.; 5 days per week; 4 weeks
Result:

Downregulated heat shock-related 70 kDa protein 2 (HSP70.2) spots by 2.1-fold and 4.2-fold.
Downregulated 60 kDa heat shock protein mitochondrial precursor (HSP60) by 2.8-fold.
Downregulated protein disulfide-isomerase A3 precursor (ERp60) by 2.0-fold.
Upregulated an unidentified 47 kDa protein by 2.8-fold.
Downregulated an unidentified 41 kDa protein by 2.3-fold.
Upregulated an unidentified 38 kDa protein by 2.6-fold.
Downregulated an unidentified 37 kDa protein by 3.5-fold.
All significant changes showed greater than two-fold variation relative to controls with p < 0.05.

Animal Model:

Sprague-Dawley (male, 7-week-old, 280 g)^[2]
Dosage:

200 mg/kg
Administration:

p.o.; 5 days per week; 4 weeks
Result:

Reduced feed consumption by 20% relative to controls.
Reduced final mean body weight by 17% relative to controls.
Lowered relative thymus weight by 48% relative to controls.
Lowered relative testis weight by 21% relative to controls.
Increased urinary creatine/creatinine molar ratio to 11-fold higher than controls.
Increased hepatic BROD activity to 0.117 nmol/min/mg prot relative to control 0.048 nmol/min/mg prot.
Increased hepatic UDPGT activity to 1.54 nmol/min/mg prot relative to control 1.03 nmol/min/mg prot.
Increased hepatic GST activity to 2.75 μmol/min/mg prot relative to control 1.87 μmol/min/mg prot.
Elevated urinary ascorbic acid levels significantly relative to controls.
Reduced liver thiobarbituric acid-reactive substances (TBARS) to 45% of control levels.
Decreased serum TBARS significantly relative to controls.
Increased urinary 2-methoxyacetic acid (MAA) levels to 6.4 times higher than controls.
Achieved a mean plasma MAA concentration of 0.34 mM.
Induced moderate degeneration of seminiferous tubules, interstitial vacuolation in testes, moderate to severe reduction in sperm density in the epididymis tail, presence of spermatid giant cells and cell debris in the epididymis, reduced cortical and medullary volume in the thymus, mild dyserythropoiesis and dysthrombopoiesis in bone marrow, mild thyroid changes, and mild adaptive histological changes in the liver.

Related Protocols :

Chemical Information

CAS. Nr. 13179-98-1
Appearance Liquid
Molecular Weight 146.23
Formel C₈H₁₈O₂
SMILES

COCCCCCCOC
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (683.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.8385 mL

34.1927 mL

68.3854 mL

5 mM

1.3677 mL

6.8385 mL

13.6771 mL

10 mM

0.6839 mL

3.4193 mL

6.8385 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (17.10 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (17.10 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (17.10 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Pelletier G, et al.. Proteomic investigation of 1,6-dimethoxyhexane testicular toxicity. Environmental toxicology and pharmacology. 2007 Sep;24(2):129-33. [Content Brief]

[2]. Poon R, et al.. Short-term oral toxicity of butyl ether, ethyl hexyl ether, methyl heptyl ether and 1,6-dimethoxyhexane in male rats and the role of 2-methoxyacetic acid. Toxicology. 2005 Oct 15;214(1-2):99-112. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.8385 mL	34.1927 mL	68.3854 mL	170.9636 mL
	5 mM	1.3677 mL	6.8385 mL	13.6771 mL	34.1927 mL
	10 mM	0.6839 mL	3.4193 mL	6.8385 mL	17.0964 mL
	15 mM	0.4559 mL	2.2795 mL	4.5590 mL	11.3976 mL
	20 mM	0.3419 mL	1.7096 mL	3.4193 mL	8.5482 mL
	25 mM	0.2735 mL	1.3677 mL	2.7354 mL	6.8385 mL
	30 mM	0.2280 mL	1.1398 mL	2.2795 mL	5.6988 mL
	40 mM	0.1710 mL	0.8548 mL	1.7096 mL	4.2741 mL
	50 mM	0.1368 mL	0.6839 mL	1.3677 mL	3.4193 mL
	60 mM	0.1140 mL	0.5699 mL	1.1398 mL	2.8494 mL
	80 mM	0.0855 mL	0.4274 mL	0.8548 mL	2.1370 mL
	100 mM	0.0684 mL	0.3419 mL	0.6839 mL	1.7096 mL

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1,6-Dimethoxyhexane

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