653-47
653-47, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 is also a very weak CREB inhibitor with IC50 of 26.3 μM.
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- CAS. Nr.: 1224678-75-4
- Formel: C20H19ClN2O3
- Molecular Weight:370.83
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
In Vitro
653-47 (5-10 μM) synergistically inhibits CREB-mediated gene transcription with 666-15[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS. Nr. 1224678-75-4
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Molecular Weight 370.83
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Formel C20H19ClN2O3
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SMILES
O=C(C1=C(OCCCN)C=C2C=CC=CC2=C1)NC3=CC=C(Cl)C=C3O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
653-47 Related Classifications
HY-134598 Related Classifications
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