Art. -Nr.: HY-N0148A

Rutin hydrate

(Synonyms: Rutoside hydrate; Quercetin 3-O-rutinoside hydrate)

34 Cited Publications

Kundenbewertung

Based on 34 publication(s) in Google Scholar

Rutin (Rutoside) hydrate is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin hydrate can cross the blood brain barrier. Rutin hydrate attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress.

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Reinheit: 98.33%
CAS. Nr.: 207671-50-9
Formel: C₂₇H₃O₁₆.36/5H₂O
Molecular Weight:713.04

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Rutin hydrate Chemical Structure

CAS. Nr.: 207671-50-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vivo
- Clinical Trial
Chemical Information
Publications (34)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Protokoll
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vivo

Rutin hydrate ameliorates cadmium chloride-induced spatial memory loss and neural apoptosis in rats by enhancing levels of acetylcholine, inhibiting JNK and ERK1/2 activation and activating mTOR signaling^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 207671-50-9
Appearance Solid
Molecular Weight 713.04
Formel C₂₇H₃O₁₆.36/5H₂O
Color Light yellow to yellow
SMILES

O=C1C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO[C@H]3[C@@H]([C@@H]([C@H]([C@H](C)O3)O)O)O)O2)O)O)O)=C(C4=CC=C(O)C(O)=C4)OC5=CC(O)=CC(O)=C15.O.[36/5]
Synonyms

Rutoside hydrate; Quercetin 3-O-rutinoside hydrate
Structure Classification
- Flavonoids
- Flavonols
- Phenols
- Polyphenols
Initial Source
- Plants
- other families
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (34)

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Journal Impact Factor

Signal Transduct Target Ther

Short-chain acyl-CoA dehydrogenase initiates mtDNA demethylation and leakage to fuel antitumor immunity in colorectal cancer. [Abstract]

2026 Mar 26;11(1):113. PMID: 41888107
Cell Death Differ

Redox regulation of TRIM28 facilitates neuronal ferroptosis by promoting SUMOylation and inhibiting OPTN-selective autophagic degradation of ACSL4. [Abstract]

2025 Jun;32(6):1041-1057. PMID: 39875520
Neuron

Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury. [Abstract]

2025 Jul 23;113(14):2280-2296.e8. PMID: 40328251
Adv Sci (Weinh)

SRSF5-Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host-Directed Target Against Influenza Virus. [Abstract]

2022 Dec;9(34):e2203088. PMID: 36257906
Food Chem

Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]

2025 Dec 30:497:146992. PMID: 41285060
Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 May 31:489:144992. PMID: 40466530
Food Chem

Discovery of novel ascorbic acid derivatives and other metabolites in fruit of Rosa roxburghii Tratt through untargeted metabolomics and feature-based molecular networking. [Abstract]

2023 Mar 30;405(Pt A):134807. PMID: 36370576
Food Chem

New insights into the influences of baking and storage on the nonvolatile compounds in oolong tea: A nontargeted and targeted metabolomics study. [Abstract]

2022 May 1:375:131872. PMID: 34953237
Phytomedicine

Combined transcriptomics and network pharmacology to elucidate the mechanisms of rutin in treating ischemic stroke rat. [Abstract]

2025 Sep 15:148:157267. PMID: 40975038

Rutin hydrate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep 15:148:157267. [Abstract]

Rutin (80 mg/kg, q.d., 3 days) reduces pathological damage. Scale bar = 50 μm, n = 6 per group.

Rutin hydrate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep 15:148:157267. [Abstract]

Effect of rutin (80 mg/kg, q.d., 3 days) on NF-κB/NLRP3 signaling and cell localization in tMCAO rats. (A-H) Western blot analysis of the protein expression level of NF-κB p65, NLRP3, Caspase-1, GSDMD in MCAO/R rats brain tissues and grayscale scanning analysis. Scale bar = 20 μm. n = 3 per group.

Rutin hydrate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep 15:148:157267. [Abstract]

Effect of rutin (80 mg/kg, q.d., 3 days) on NF-κB/NLRP3 signaling and cell localization in tMCAO rats. ELISA analysis of IL-1β, IL-18, IL-6, TNF-α levels in serum. Scale bar = 20 μm. n = 3 per group.

Rutin hydrate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep 15:148:157267. [Abstract]

Effect of rutin (80 mg/kg, q.d., 3 days) on NF-κB/NLRP3 signaling and cell localization in tMCAO rats. Representative immunofluorescence staining pictures of NLRP3 in brain tissues. Scale bar = 20 μm. n = 3 per group.

Rutin hydrate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep 15:148:157267. [Abstract]

Effect of rutin (40 μM, 24 h) on OGD/R-induced primary astrocyte during reperfusion. Representative immunofluorescence staining pictures of NLRP3, GSDMD in OGD/R-induced primary astrocyte. Scale bar = 20 μm, n = 3 per group.

Rutin hydrate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep 15:148:157267. [Abstract]

Effect of rutin (5, 10, 20, and 40 μM, 24 h) on OGD/R-induced primary astrocyte. Cell viability was determined with CCK-8 kit.
Phytomedicine

Rutin alleviates EndMT by restoring autophagy through inhibiting HDAC1 via PI3K/AKT/mTOR pathway in diabetic kidney disease. [Abstract]

2023 Apr:112:154700. PMID: 36774842
Food Res Int

Optimal Brassicaceae family microgreens from a phytochemical and sensory perspective. [Abstract]

2024 Oct:193:114812. PMID: 39160037
Antioxidants (Basel)

Bioactive Extracts and Constituents from Taraxacum mongolicum: Antioxidant, Anti-Inflammatory, Enzyme-Inhibitory, and Molecular Docking Studies. [Abstract]

2026 May 29;15(6):688. PMID: 42351994
Antioxidants (Basel)

Phenolic Profile and Bioactivity Changes of Lotus Seedpod and Litchi Pericarp Procyanidins: Effect of Probiotic Bacteria Biotransformation. [Abstract]

2023 Nov 7;12(11):1974. PMID: 38001827
Ind Crops Prod

2025 Dec 11;239:122458.
Food Funct

Blackthorn juice from central Italy exhibits selective anticancer activity by inducing apoptosis and autophagy in gastric carcinoma cells. [Abstract]

2025 Oct 27;16(21):8548-8563. PMID: 41085359
Int Immunopharmacol

Rutin ameliorates hepatic ischemia-reperfusion injury by targeting CD36 to suppress hepatocyte ferroptosis. [Abstract]

2026 Mar 1:172:116231. PMID: 41576568
Eur J Pharmacol

Rutin protects the pancreas from inflammatory injury and oncogene-driven tumorigenesis by inhibiting acinar to ductal metaplasia. [Abstract]

2025 Jul 5:998:177536. PMID: 40120793
ACS Omega

Identification of New Modulators and Inhibitors of Palmitoyl-Protein Thioesterase 1 for CLN1 Batten Disease and Cancer. [Abstract]

2024 Feb 28;9(10):11870-11882. PMID: 38496939
iScience

Rutin alleviates ventilator-induced lung injury by inhibiting NLRP3 inflammasome activation. [Abstract]

2023 Sep 9;26(10):107866. PMID: 37817937
Polym Bull (Berl)

2026 Mar 26;83(6):314.
Neurotoxicology

Rutin alleviates Pb-induced oxidative stress, inflammation and cell death via activating Nrf2/ARE system in SH-SY5Y cells. [Abstract]

2024 Jul 18:S0161-813X(24)00082-2. PMID: 39032614
Hum Mutat

SELL Marks an Effector-Deficient CD8+ T Cell Subset That Promotes Intracerebral Hemorrhage and Responds to Rutin Therapy. [Abstract]

2026 Apr 2:2026:4033506. PMID: 41937927
Metabolites

2025 Dec 23;16(1):12.
Metabolites

Rutin Maintains the Thermogenic Phenotype of Beige Adipocytes and Concomitantly Suppresses Mitophagy Against Obesity in HFD Mice. [Abstract]

2025 Dec 23;16(1):12. PMID: 41590620
Biology (Basel)

Antibacterial, Antibiofilm, and Wound Healing Activities of Rutin and Quercetin and Their Interaction with Gentamicin on Excision Wounds in Diabetic Mice. [Abstract]

2024 Aug 29;13(9):676. PMID: 39336103
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
Arch Endocrinol Metab

miR-590-5p mediates mitochondrial respiration, proliferation, and apoptosis in thyroid carcinoma cells via fibroblast growth factor receptor substrate 2. [Abstract]

2025 Aug 20;69(4):e240410. PMID: 40834280
Lett Drug Des Discov

2026 Feb 11.
Pharmacogn Mag

2023 Oct 12.
SSRN

2026 Jun 21.
Eur Rev Med Pharmacol Sci

Mulberry leaf extracts and quercetin glycosides promote glycogen accumulation in astrocytes. [Abstract]

2025 Sep;29(9):425-433. PMID: 41059752
SSRN

2025 Oct 6.
Regulatory Research and Medicine Evaluation

2025.
SSRN

2025 Mar 20.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (140.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.4024 mL

7.0122 mL

14.0245 mL

5 mM

0.2805 mL

1.4024 mL

2.8049 mL

10 mM

0.1402 mL

0.7012 mL

1.4024 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (3.51 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (3.51 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (3.51 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 1% CMC-Na/saline water

Solubility: 3.33 mg/mL (4.67 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protokoll

Animal Administration^[1]

Rats^[1]
(1) A control group receives of 0.01 g/mL carboxymethylcellulose (CMC) dissolved in distilled water; (2) α-tocopherol acetate treated group: control rats receive α-tocopherol (120 IU/rat) diluted in 0.1 mL of coconut oil; (3) Rutin hydrate treated control group (control + Rutin hydrate): control rats receive Rutin hydrate (100 mg/kg); (4) CdCl₂ intoxicated group receives CdCl₂ at a final dose of 5 mg/kg to induce neurotoxicity; (5) CdCl₂ + Rutin hydrate treated group (CdCl₂ + Rutin hydrate) receives CdCl₂ (5 mg/kg) and receives a coincided dose of Rutin hydrate (100 mg/kg body weight); (6) CdCl₂ + Rutin hydrate + α-tocopherol acetate-treated group receives CdCl₂ (5 mg/kg) and receives concomitant dose of Rutin hydrate (100 mg/kg) in conjugation with α-tocopherol acetate (120 IU/rat) that is diluted in 0.1 mL of coconut oil. All treatments are given by orogastric gavage with a polyethylene catheter PE 190 daily for 30 days^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (286 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ghorbani A. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother. 2017;96:305-312. [Content Brief]

[2]. Habtemariam S. Rutin as a Natural Therapy for Alzheimer's Disease: Insights into its Mechanisms of Action. Curr Med Chem. 2016;23(9):860-873. [Content Brief]

[3]. Xu PX, et al. Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation. Behav Brain Res. 2014;264:173-180. [Content Brief]

[4]. Abdel-Aleem GA, et al. Rutin hydrate ameliorates cadmium chloride-induced spatial memory loss and neural apoptosis in rats by enhancing levels of acetylcholine, inhibiting JNK and ERK1/2 activation and activating mTOR signalling. Arch Physiol Biochem. 2018;124(4):367-377. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.4024 mL	7.0122 mL	14.0245 mL	35.0611 mL
	5 mM	0.2805 mL	1.4024 mL	2.8049 mL	7.0122 mL
	10 mM	0.1402 mL	0.7012 mL	1.4024 mL	3.5061 mL
	15 mM	0.0935 mL	0.4675 mL	0.9350 mL	2.3374 mL
	20 mM	0.0701 mL	0.3506 mL	0.7012 mL	1.7531 mL
	25 mM	0.0561 mL	0.2805 mL	0.5610 mL	1.4024 mL
	30 mM	0.0467 mL	0.2337 mL	0.4675 mL	1.1687 mL
	40 mM	0.0351 mL	0.1753 mL	0.3506 mL	0.8765 mL
	50 mM	0.0280 mL	0.1402 mL	0.2805 mL	0.7012 mL
	60 mM	0.0234 mL	0.1169 mL	0.2337 mL	0.5844 mL
	80 mM	0.0175 mL	0.0877 mL	0.1753 mL	0.4383 mL
	100 mM	0.0140 mL	0.0701 mL	0.1402 mL	0.3506 mL

Rutin hydrate

34 Cited Publications

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Rutin hydrate

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Publications Citing Use of MedChemExpress (MCE) Rutin hydrate

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (34)

Lösungsmittel & Löslichkeit

Protokoll

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Rutin hydrate Related Classifications

HY-N0148A Related Classifications