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S63845

111 Cited Publications
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Based on 111 publication(s) in Google Scholar

S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a Kd of 0.19 nM for human MCL1.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

  • Reinheit: 99.81%
  • CAS. Nr.: 1799633-27-4
  • Formel: C39H37ClF4N6O6S
  • Molecular Weight:829.26
  • Speicherung:

    4°C, protect from light, stored under nitrogen

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

  • S63845 Chemical Structure
    S63845 Chemical Structure
  • Experimental Validation Results for S63845
  • Experimental Validation Results for S63845
  • Experimental Validation Results for S63845
  • Experimental Validation Results for S63845
  • Experimental Validation Results for S63845
  • Experimental Validation Results for S63845
  • Experimental Validation Results for S63845
  • Experimental Validation Results for S63845
CAS. Nr.: 1799633-27-4
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WBBio/Physico-chemical AssayApoptosis AnalysisCell Proliferation/Viability Assay
  • Bio/Physico-chemical Assay
  • Cell Proliferation/Viability Assay
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  • Apoptosis Analysis
  • Cell Proliferation/Viability Assay
  • Cell Proliferation/Viability Assay
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  • S63845 Chemical Structure
    S63845 Chemical Structure
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    S63845 purchased from MedChemExpress. Usage Cited in: Nat Cancer. 2024 Jul;5(7):1082-1101. [Abstract]

    Customer Validation
     Growth inhibition curves (left panel), IC50 values, and AUCs (right panel) of OCI-AML2 cells treated with DMSO or 500nM ARM165 in combination with increasing doses (10-10000 nM）of either venetoclax, S63845, WEHI-539 and A-1331852. Error bars represent mean ± SD of three biological replicates composed of seven technical repeats after three days of seeding.

  • 1/16

    S63845 purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2025 May;32(5):855-865. [Abstract]

    Customer Validation
     Before-after graphs of the normalized survival of parental and senescent cells treated with 0.5 µM ABT-263, 0.8 µM S63845 or combination of both for 5 days. Read-out is the mean obtained from three independent cell titer blue assays. Data was analyzed with paired t-tests, N = 12.

  • 1/16

    S63845 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 May 9;8(1):194. [Abstract]

    Customer Validation
     A549 cells were transfected with plasmids encoding CoV-N for 24 h, they were pre-treated with 3 μM S63845 for 4 h, then stimulated with 5 μM Staurosporine or DMSO for another 4 h. Cell lysates were analyzed by immunoblotting.

  • 1/16

    S63845 purchased from MedChemExpress. Usage Cited in: Cell. 2022 Apr 28;185(9):1521-1538.e18. [Abstract]

    Customer Validation
     Low nM concentrations (e.g., 4 nM) of MCL-1i S63845 (8-32 nM) or BCL-2i ABT-199 effectively primed cancer cells for apoptosis induction. OCI-AML3 cells were treated with indicated doses of BCL-2i and MCL-1i combinations for 24 h. Each tile represents the mean of triplicate experiments.

  • 1/16

    S63845 purchased from MedChemExpress. Usage Cited in: Mol Cell. 2020 Jul 2;79(1):68-83.e7. [Abstract]

    Customer Validation
     Cell viability of Bax−/−Bak−/− MEFs and those reconstituted with WT or R134E/R145E-mutant BAX in response to treatment with the indicated doses of S63845 and ABT-737. Data are mean ± s.d. for experiments performed in technical triplicate and repeated twice with similar results using independent cell cultures and treatments.

  • 1/16

    S63845 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Jun 8;11(6):443. [Abstract]

    Customer Validation
     In A375 cells, knockdown (KD) of MCL1 (shMCL1), BCL2 (shBCL2), BCLW (shBCLW), and BCLXL (shBCLXL) lines are created by shRNA technology. shBCLXL (in presence of S63845) shows significant reduction in cell viability during 48 h drug treatment.

  • 1/16

    S63845 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Jun 8;11(6):443. [Abstract]

    Customer Validation
     Immunoblot with cell lysates collected after 48 h treatment with DMSO, single drugs: S63845 (156 nM) and A-1331852 (156 nM), or combinations, and probed for PARP. Both combinations increased the cleaved product of PARP. Molecular weight markers are in kDa.

  • 1/16

    S63845 purchased from MedChemExpress. Usage Cited in: Clin Cancer Res. 2018 Nov 1;24(21):5458-5470. [Abstract]

    Customer Validation
     Primary LuCaP35CR and LuCaP70CR cultures are treated with ABT-263 alone, S63845 (500 nM) alone, or combination for 4 hours in 2D culture. The cell lysates then are immunoblotted for indicated proteins.

  • S63845