Art. -Nr.: HY-114404

SJFα

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Based on 1 Customer Validation

SJFα is a selective p38α PROTAC degrader with a DC₅₀ of 7.16 nM and D_max of 97.4%. SJFα is far less effective at degrading p38δ (DC₅₀ = 299 nM). SJFαcan be used for the research of cancer, such as breast cancer.
(Pink: p38α ligand (HY-45124); Blue: VHL ligand (HY-125845); Black: linker).

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Reinheit: 99.61%
CAS. Nr.: 2254609-27-1
Formel: C₅₉H₆₇F₂N₇O₁₁S
Molecular Weight:1120.27

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

SJFα Chemical Structure

CAS. Nr.: 2254609-27-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

SJFα is a selective p38α PROTAC degrader with a DC₅₀ of 7.16 nM and D_max of 97.4%. SJFα is far less effective at degrading p38δ (DC₅₀ = 299 nM). SJFαcan be used for the research of cancer, such as breast cancer^[1]. (Pink: p38α ligand (HY-45124); Blue: VHL ligand (HY-125845); Black: linker).

IC₅₀ & Target^[1]

p38α

7.16 nM (DC₅₀)

p38δ

299 nM (DC₅₀)

VHL

Alle PROTACs Isoform-spezifische Produkte anzeigen :

Alle p38 MAPK Isoform-spezifische Produkte anzeigen :

In Vitro

SJFα (0.025-2.5 μM, 6-72 h) degrades p38α in MDA-MB-231 cells^[1].
SJFα(0.025-2.5 μM) does not degrade the other p38 isoforms (β and γ) in MDA-MB-231 cells^[1].
SJFα (0.025-2.5 μM) reduces p38δ:PROTAC:VHL complex in MDA-MB-231 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MDA-MB-231 cells
Concentration:

0.025, 0.25 and 2.5 μM
Incubation Time:

6, 24, 48 and 72 h
Result:

Reduced p38α levels.

Chemical Information

CAS. Nr. 2254609-27-1
Appearance Solid
Molecular Weight 1120.27
Formel C₅₉H₆₇F₂N₇O₁₁S
Color White to off-white
SMILES

FC1=CC=C(NC(C2(CC2)C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OCCCCOCCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)=C8)C8=NC=C4)C=C3)=O)=O)C=C1
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (89.26 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.8926 mL

4.4632 mL

8.9264 mL

5 mM

0.1785 mL

0.8926 mL

1.7853 mL

10 mM

0.0893 mL

0.4463 mL

0.8926 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10(1):131. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.8926 mL	4.4632 mL	8.9264 mL	22.3160 mL
	5 mM	0.1785 mL	0.8926 mL	1.7853 mL	4.4632 mL
	10 mM	0.0893 mL	0.4463 mL	0.8926 mL	2.2316 mL
	15 mM	0.0595 mL	0.2975 mL	0.5951 mL	1.4877 mL
	20 mM	0.0446 mL	0.2232 mL	0.4463 mL	1.1158 mL
	25 mM	0.0357 mL	0.1785 mL	0.3571 mL	0.8926 mL
	30 mM	0.0298 mL	0.1488 mL	0.2975 mL	0.7439 mL
	40 mM	0.0223 mL	0.1116 mL	0.2232 mL	0.5579 mL
	50 mM	0.0179 mL	0.0893 mL	0.1785 mL	0.4463 mL
	60 mM	0.0149 mL	0.0744 mL	0.1488 mL	0.3719 mL
	80 mM	0.0112 mL	0.0558 mL	0.1116 mL	0.2790 mL

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SJFα

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Kinase Inhibitor Library

MAPK Compound Library

Anti-Cancer Compound Library

Alle PROTACs Isoform-spezifische Produkte anzeigen

Alle p38 MAPK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

SJFα Related Classifications

HY-114404 Related Classifications