SR121566A
SR121566A is a novel non-peptide Glycoprotein IIb/IIIa (GP IIb-IIIa) antagonist, which can inhibit ADP-, arachidonic acid- and collagen-induced human platelet aggregation with IC50s of 46±7.5, 56±6 and 42±3 nM, respectively.
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- CAS. Nr.: 180144-61-0
- Formel: C20H25N5O4S
- Molecular Weight:431.51
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
GP IIb-IIIa[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Platelet | IC50 |
0.046 μM
Compound: 6k
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Inhibition of ADP-induced human platelet aggregation
Inhibition of ADP-induced human platelet aggregation
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[PMID: 17350143] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 180144-61-0
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Molecular Weight 431.51
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Formel C20H25N5O4S
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SMILES
O=C(O)CN1CCC(N(C2=NC(C3=CC=C(C(N)=N)C=C3)=CS2)CCC(O)=O)CC1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
Male mice (26-30 g) are anesthetized, artificially ventilated, and placed on a heated jacket to control body temperature. A femoral vein is cannulated for i.v. injections. In thrombosis experiments, drugs including SR121566A are administered in 0.9% saline for intravenous studies (0.1 mL/30 g, 5 min before stimulation) and in water for oral studies (0.1 mL/30 g, 120 min before stimulation)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Reinheit & Dokumentation
Verweise
[1]. Herault JP, et al. Effect of SR121566A, a potent GP IIb-IIIa antagonist on platelet-mediated thrombin generation in vitro and in vivo. Thromb Haemost. 1998 Feb;79(2):383-8. [Content Brief]
[2]. Lorrain J, et al. Effects of SanOrg123781A, a synthetic hexadecasaccharide, in a mouse model of electrically induced carotid artery injury: synergism with the antiplatelet agent clopidogrel. J Pharmacol Exp Ther. 2004 Apr;309(1):235-40. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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