ANGPTL
Angiopoietin-like protein
Angiopoietin-like proteins (ANGPTLs) are identified as proteins structurally similar to angiopoietins, and the ANGPTL family now consists of eight members. ANGPTLs are secretary proteins, and some ANGPTLs are not only angiogenic factors but also proteins with multiple functions such as glucose metabolism, lipid metabolism, redox regulation and chronic inflammation.
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ANGPTL Verwandte Produkte (21)
Verwandte Produkte (21)
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ANGPTL Isoform Comparison
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Evinacumab
0 ImagesSynonyms: REGN1500Evinacumab (REGN1500) is a human anti-ANGPTL3 (angiopoietin-like protein 3) monoclonal antibody (IgG4 class antibody). Evinacumab reduces plasma lipids in dyslipidemic mice by blocking ANGPTL3. Evinacumab can be used in studies of homozygous familial hypercholesterolaemia (HoFH), refractory hypercholesterolaemia (both familial and non-familial) and severe hypertriglyceridaemia.
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Vupanorsen sodium
0 ImagesArt. -Nr.: HY-153497ACAS. Nr.: 2172852-12-7Synonyms: IONIS ANGPT-L3Rx sodium; ISIS 703802 sodiumVupanorsen (sodium) is an N-acetyl galactosamine-conjugated antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein synthesis. Vupanorsen (sodium) lowers triglycerides and atherogenic lipoproteins.
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Anti-ANGPTL4 Antibody
0 ImagesArt. -Nr.: HY-P990335Anti-ANGPTL4 Antibody is a CHO expressed human antibody targeting ANGPTL4. Anti-ANGPTL4 Antibody has a huIgG1-type heavy chain and a huλ-type light chain with a predicted molecular weight (MW) of 150 kDa. An isotype control for Anti-ANGPTL4 Antibody can be found in Human IgG1 kappa, Isotype Control (HY-P99001).
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Zodasiran
0 ImagesArt. -Nr.: HY-177671CAS. Nr.: 2232918-66-8Synonyms: ARO-ANG3Zodasiran (ARO-ANG3) is an siRNA targeting ANGPTL3 that mediates RNAi degradation of ANGPTL3 mRNA, reducing hepatic ANGPTL3 protein synthesis and mRNA expression. Zodasiran can be used in research related to diseases such as atherosclerotic cardiovascular disease and mixed dyslipidemia.
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Pegevongitide
0 ImagesSynonyms: AV-001Pegevongitide (AV-001) is a Tie2 agonist. Pegevongitide resists the increased endothelial cell permeability induced by SARS-CoV-2 infection. Pegevongitide activates the angiogenin (angiogenin)/Tie2 signaling pathway. Pegevongitide reduces perivascular space dilation and upregulates perivascular Aquaporin-4 expression. Pegevongitide decreases the expression of TNF-α, PAI-1, CXCL9 and P-selectin, improves white matter integrity, enhances cognitive function and exerts neuroprotective effects. Pegevongitide improves white matter integrity in middle-aged rats with vascular dementia induced by multiple microinfarctions. Pegevongitide can be used in related research on diseases such as COVID-19 and vascular dementia.
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Zodasiran sodium
0 ImagesArt. -Nr.: HY-177671ACAS. Nr.: 2232918-74-8Synonyms: ARO-ANG3 sodiumZodasiran sodium (ARO-ANG3 sodium) is an siRNA targeting ANGPTL3 that mediates RNAi degradation of ANGPTL3 mRNA, reducing hepatic ANGPTL3 protein synthesis and mRNA expression. Zodasiran sodium can be used in research related to diseases such as atherosclerotic cardiovascular disease and mixed dyslipidemia.
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Cy3 labled Zodasiran sodium
0 ImagesArt. -Nr.: HY-177671DCy3 labled Zodasiran sodium is a Cy3 (HY-D0822) labled Zodasiran sodium (HY-177671A). Zodasiran sodium (ARO-ANG3 sodium) is an siRNA targeting ANGPTL3 that mediates RNAi degradation of ANGPTL3 mRNA, reducing hepatic ANGPTL3 protein synthesis and mRNA expression. Zodasiran sodium can be used in research related to diseases such as atherosclerotic cardiovascular disease and mixed dyslipidemia.
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JTE-907
0 ImagesJTE-907 is a selective and orally active cannabinoid CB2 receptor inverse agonist and exerts anti-inflammatory effects. JTE-907 upregulates IL-6, MCP-1, IL-1β, VEGF, ANGPTL4, and TRPV1 in mature adipocytes. JTE-907 downregulates CB1, MCP-1, and IL-1β in preadipocytes. JTE-907 inhibits ear swelling in mice. JTE-907 reverses the protective effects of CB2 agonists and Anandamide (HY-10863) against cytokine-evoked colonic mucosal damage. JTE-907 can be used for the research of allergic dermatitis, obesity, and colitis.
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DC371739
0 ImagesArt. -Nr.: HY-163794CAS. Nr.: 2135765-21-6
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Vupanorsen
0 ImagesArt. -Nr.: HY-153497CAS. Nr.: 2097587-62-5Synonyms: IONIS ANGPT-L3Rx; ISIS 703802Vupanorsen is an N-acetyl galactosamine-conjugated antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein synthesis. Vupanorsen lowers triglycerides and atherogenic lipoproteins.
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Solbinsiran sodium
0 ImagesArt. -Nr.: HY-177666ACAS. Nr.: 2707429-60-3Synonyms: LY3561774 sodiumSolbinsiran sodium (LY3561774 sodium) is a GalNAc-conjugated siRNA targeting ANGPTL3. Solbinsiran sodium mediates RNA interference against hepatic ANGPTL3 mRNA, reducing ANGPTL3 translation. Solbinsiran sodium lowers hepatocyte ANGPTL3 mRNA and serum ANGPTL3 protein levels. Solbinsiran sodium can be used in research on mixed dyslipidemia.
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Lexosiran
0 ImagesArt. -Nr.: HY-185318CAS. Nr.: 3078403-66-1Lexosiran is a siRNA that inhibits ANGPTL3 (angiopoietin-related protein 3) synthesis, and can be use for the study of antihyperlipidaemic.
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Zodasiran sodium scrambled negative control
0 ImagesArt. -Nr.: HY-177671BZodasiran sodium scrambled negative control is the sequence scrambled negative control of Zodasiran sodium (HY-177671A). Zodasiran sodium (ARO-ANG3 sodium) is an siRNA targeting ANGPTL3 that mediates RNAi degradation of ANGPTL3 mRNA, reducing hepatic ANGPTL3 protein synthesis and mRNA expression. Zodasiran sodium can be used in research related to diseases such as atherosclerotic cardiovascular disease and mixed dyslipidemia.
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Solbinsiran sodium scrambled negative control
0 ImagesArt. -Nr.: HY-177666BSolbinsiran sodium scrambled negative control is the sequence scrambled negative control of Solbinsiran sodium.
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Lexosiran sodium
0 ImagesArt. -Nr.: HY-185318ALexosiran sodium is a siRNA that inhibits ANGPTL3 angiopoietin-related protein 3 synthesis, and can be use for the study of antihyperlipidaemic.
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Solbinsiran
0 ImagesArt. -Nr.: HY-177666CAS. Nr.: 2718150-11-7Synonyms: LY3561774Solbinsiran (LY3561774) is a GalNAc-conjugated siRNA targeting ANGPTL3. Solbinsiran mediates RNA interference against hepatic ANGPTL3 mRNA, reducing ANGPTL3 translation. Solbinsiran lowers hepatocyte ANGPTL3 mRNA and serum ANGPTL3 protein levels. Solbinsiran can be used in research on mixed dyslipidemia.
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FAM labled Zodasiran sodium
0 ImagesArt. -Nr.: HY-177671CFAM labled Zodasiran sodiumis a FAM labled Zodasiran sodium (HY-177671A). Zodasiran sodium (ARO-ANG3 sodium) is an siRNA targeting ANGPTL3 that mediates RNAi degradation of ANGPTL3 mRNA, reducing hepatic ANGPTL3 protein synthesis and mRNA expression. Zodasiran sodium can be used in research related to diseases such as atherosclerotic cardiovascular disease and mixed dyslipidemia.
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Cartilostatin 1
0 ImagesArt. -Nr.: HY-P4000CAS. Nr.: 929555-05-5Cartilostatin 1 is an anti-angiogenic peptide. Cartilostatin 1 can be used for the research of anti-angiogenic.
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Vupanorsen sodium scrambled negative control
0 ImagesArt. -Nr.: HY-153497CVupanorsen sodium scrambled negative control is the sequence scrambled negative control of Vupanorsen sodium.
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