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Art. -Nr.: HY-N7227

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Anonaine

Anonaine is an antiparasitic agent. Anonaine also is a glutathione S-transferase (GST) inhibitor.

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Reinheit: 95.0%
CAS. Nr.: 1862-41-5
Formel: C₁₇H₁₅NO₂
Molecular Weight:265.31

Speicherung:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Anonaine Chemical Structure

CAS. Nr.: 1862-41-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Anonaine is an antiparasitic agent. Anonaine also is a glutathione S-transferase (GST) inhibitor^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
A-431	ED₅₀	4.2 μg/mL Compound: 3	Cytotoxicity against human A431 cells after 3 days by SRB assay Cytotoxicity against human A431 cells after 3 days by SRB assay	[PMID: 8254346]
AGS	IC₅₀	8.6 μM Compound: 5	Cytotoxicity against human AGS cells by MTS colorimetric assay Cytotoxicity against human AGS cells by MTS colorimetric assay	[PMID: 11087586]
DLD-1	IC₅₀	28.9 μM Compound: 5	Cytotoxicity against human DLD1 cells by MTS colorimetric assay Cytotoxicity against human DLD1 cells by MTS colorimetric assay	[PMID: 11087586]
HeLa	IC₅₀	24.8 μg/mL Compound: Anonaine, III	Cytotoxicity against human HeLa cells after 24 hrs by MTT assay Cytotoxicity against human HeLa cells after 24 hrs by MTT assay	[PMID: 18295494]
Hepatocyte	IC₅₀	70.3 μg/mL Compound: Anonaine, III	Cytotoxicity against Sprague-Dawley rat primary hepatocytes after 24 hrs by MTT assay Cytotoxicity against Sprague-Dawley rat primary hepatocytes after 24 hrs by MTT assay	[PMID: 18295494]
HepG2	IC₅₀	20.8 μM Compound: 5	Cytotoxicity against human HepG2 cells by MTS colorimetric assay Cytotoxicity against human HepG2 cells by MTS colorimetric assay	[PMID: 11087586]
HepG2	IC₅₀	33.5 μg/mL Compound: Anonaine, III	Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 18295494]
HT-1080	ED₅₀	2.4 μg/mL Compound: 3	Cytotoxicity against human HT1080 cells after 3 days by SRB assay Cytotoxicity against human HT1080 cells after 3 days by SRB assay	[PMID: 8254346]
KB	ED₅₀	2.6 μg/mL Compound: 3	Cytotoxicity against human KB cells after 3 days by SRB assay Cytotoxicity against human KB cells after 3 days by SRB assay	[PMID: 8254346]
KB-V1	ED₅₀	1.8 μg/mL Compound: 3	Cytotoxicity against vinblastine-resistant human KBV1 cells after 3 days by SRB assay Cytotoxicity against vinblastine-resistant human KBV1 cells after 3 days by SRB assay	[PMID: 8254346]
LNCaP	ED₅₀	2.9 μg/mL Compound: 3	Cytotoxicity against human LNCAP cells after 3 days by SRB assay Cytotoxicity against human LNCAP cells after 3 days by SRB assay	[PMID: 8254346]
P388	ED₅₀	>5 μg/mL Compound: 3	Cytotoxicity against mouse P388 cells after 3 days by SRB assay Cytotoxicity against mouse P388 cells after 3 days by SRB assay	[PMID: 8254346]
SK-MEL-2	ED₅₀	15.8 μg/mL Compound: 3	Cytotoxicity against human SK-MEL-2 cells after 3 days by SRB assay Cytotoxicity against human SK-MEL-2 cells after 3 days by SRB assay	[PMID: 8254346]
U-373MG ATCC	ED₅₀	1.5 μg/mL Compound: 3	Cytotoxicity against human U373 cells after 3 days by SRB assay Cytotoxicity against human U373 cells after 3 days by SRB assay	[PMID: 8254346]
ZR-75-1	ED₅₀	2.7 μg/mL Compound: 3	Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay	[PMID: 8254346]

Chemical Information

CAS. Nr. 1862-41-5
Appearance Solid
Molecular Weight 265.31
Formel C₁₇H₁₅NO₂
Color Light brown to brown
SMILES

[H][C@@]1(NCC2)CC3=CC=CC=C3C4=C1C2=CC5=C4OCO5
Structure Classification
- Alkaloids
- Quinoline Alkaloids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Bezerra WADS, et al. Anonaine from Annona crassiflora inhibits glutathione S-transferase and improves cypermethrin activity on Rhipicephalus (Boophilus) microplus (Canestrini, 1887). Exp Parasitol. 2022 Dec;243:108398. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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Biologische Aktivität
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Chemical Information
Reinheit & Dokumentation
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Anonaine

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