Art. -Nr.: HY-151923

ATF3 inducer 1

Name: ATF3 inducer 1
Brand: MedChemExpress
SKU: HY-151923
Price: 100.00 USD
Availability: InStock
Rating: 5 (4 reviews)

4 Cited Publications

Kundenbewertung

Based on 4 publication(s) in Google Scholar

ATF3 inducer 1 is a potent ATF3 inducer. ATF3 inducer 1 increases the ATF3 protein and ATF3 mRNA expression. ATF3 inducer 1 shows anti-MetS activity in mouse.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 99.61%
CAS. Nr.: 3038756-30-5
Formel: C₁₂H₁₀N₂O₃
Molecular Weight:230.22

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

ATF3 inducer 1 Chemical Structure

CAS. Nr.: 3038756-30-5

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

ATF3 inducer 1 is a potent ATF3 inducer. ATF3 inducer 1 increases the ATF3 protein and ATF3 mRNA expression. ATF3 inducer 1 shows anti-MetS activity in mouse^[1].

Alle Epigenetic Reader Domain Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
3T3-L1	CC₅₀	>100 μM Compound: 16c	Cytotoxicity against mouse 3T3-L1 adipocytes assessed as reduction in cell viability Cytotoxicity against mouse 3T3-L1 adipocytes assessed as reduction in cell viability	[PMID: 36455354]

In Vitro

ATF3 inducer 1 (compound 16c) (50 μM; 8 days) increases the ATF3 protein and ATF3 mRNA expression in 3T3-L1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

3T3-L1 cells
Concentration:

50 μM
Incubation Time:

8 days
Result:

Increased the ATF3 protein and ATF3 mRNA expression, showed no lipid accumalation.

In Vivo

ATF3 inducer 1 (40 mg/kg; i.p.; three times a week for 10-weeks) shows anti-MetS (managing metabolic syndrome) activity in mouse^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Eight-week-old C57BL/6 male mice^[1]
Dosage:

40 mg/kg
Administration:

I.p.; three times a week for 10-weeks
Result:

Decreased the bodyweight and the size of epididymal white adipose tissue (eWAT) adipocytes was notably diminished.

Chemical Information

CAS. Nr. 3038756-30-5
Appearance Solid
Molecular Weight 230.22
Formel C₁₂H₁₀N₂O₃
Color White to light yellow
SMILES

COC1=CC2=C(C3=C(C(C)=NN3)C(O2)=O)C=C1
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (4)

All Cell Imaging/StainingWBIHCIPHistological Imaging/Staining

Sort by:

Journal Impact Factor

J Hazard Mater

Gas6-Axl signal promotes indoor VOCs exposure-induced pulmonary fibrosis via pulmonary microvascular endothelial cells-fibroblasts cross-talk. [Abstract]

2024 Aug 5:474:134786. PMID: 38824778

ATF3 inducer 1 purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Aug 5:474:134786. [Abstract]

Cell apoptosis or necrosis in MPVECs pre-treated with DMSO or ATF3 inducer 1 (50 μM; 24 h) after mouse serum exposure in VOCs group. Representative fluorescence image after Hochest/PI staining.

ATF3 inducer 1 purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Aug 5:474:134786. [Abstract]

The relative protein expression of Gas6 in MPVECs exposed to mouse serum after pretreatment with ATF3 inducer 1 (50 μM; 24 h) was determined.

ATF3 inducer 1 purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Aug 5:474:134786. [Abstract]

After treating NIH/3T3 cells with MPVEC conditioned medium (CM), co-immunoprecipitation (co-IP) analysis of Axl was performed (MPVEC was pretreated with DMSO or ATF3 inducer 1 (50 μM; 24 h)).
Biochem Pharmacol

Calcitriol protects against diabetic kidney disease by alleviating ferroptosis in renal tubular epithelial cells via JUN/ATF3 pathway. [Abstract]

2026 Sep;251(Pt 1):118089. PMID: 42167448
Commun Biol

Pentraxin 3 ameliorates glucocorticoid-induced osteonecrosis of the femoral head via TLR4/NF-κB/FGF21 signaling axis. [Abstract]

2025 Dec 2;9(1):27. PMID: 41331332

ATF3 inducer 1 purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Dec 2;9(1):27. [Abstract]

ATF3 inducer 1 (40 mg/kg). Immunohistochemical staining of ALP, OCN and COL1 in three groups and quantitative analysis of immunohistochemical positive expression in mice in each group.

ATF3 inducer 1 purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Dec 2;9(1):27. [Abstract]

ATF3 inducer 1 (40 mg/kg). HE staining of three groups of femoral heads and quantitative analysis of HE staining results.
PLoS Pathog

Transcriptional factor ATF3 impairs KSHV lytic replication by suppressing the expression of viral bZIP protein K8. [Abstract]

2026 May 11;22(5):e1014222. PMID: 42113834

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (542.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.3437 mL

21.7184 mL

43.4367 mL

5 mM

0.8687 mL

4.3437 mL

8.6873 mL

10 mM

0.4344 mL

2.1718 mL

4.3437 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (9.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (9.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chang YH, et al. Exploration and biological evaluation of 7-methoxy-3-methyl-1H-chromeno[4,3-c]pyrazol-4-one as an activating transcription factor 3 inducer for managing metabolic syndrome. Eur J Med Chem. 2022 Nov 25;246:114951. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.3437 mL	21.7184 mL	43.4367 mL	108.5918 mL
	5 mM	0.8687 mL	4.3437 mL	8.6873 mL	21.7184 mL
	10 mM	0.4344 mL	2.1718 mL	4.3437 mL	10.8592 mL
	15 mM	0.2896 mL	1.4479 mL	2.8958 mL	7.2395 mL
	20 mM	0.2172 mL	1.0859 mL	2.1718 mL	5.4296 mL
	25 mM	0.1737 mL	0.8687 mL	1.7375 mL	4.3437 mL
	30 mM	0.1448 mL	0.7239 mL	1.4479 mL	3.6197 mL
	40 mM	0.1086 mL	0.5430 mL	1.0859 mL	2.7148 mL
	50 mM	0.0869 mL	0.4344 mL	0.8687 mL	2.1718 mL
	60 mM	0.0724 mL	0.3620 mL	0.7239 mL	1.8099 mL
	80 mM	0.0543 mL	0.2715 mL	0.5430 mL	1.3574 mL
	100 mM	0.0434 mL	0.2172 mL	0.4344 mL	1.0859 mL

Bioz

Keywords

ATF3 inducer 1

4 Cited Publications

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

ATF3 inducer 1

Publications Citing Use of MedChemExpress (MCE) ATF3 inducer 1

Alle Epigenetic Reader Domain Isoform-spezifische Produkte anzeigen