CJ-14897
CJ-14897 is a cytokine production inhibitor, with IC50 values of 0.059 μM and 0.59 μM for IL-1β and TNF-α production, respectively, and an IC50 of 180 μM for leucine uptake. CJ-14897 is isolated from the fermentation broth of the basidiomycete Marasmius strain CL21624.
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- CAS. Nr.: 377755-95-8
- Formel: C12H15NO5
- Molecular Weight:253.25
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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IL-1β 59 nM (IC50) |
CJ-14,897 potently inhibits LPS (HY-D1056)-induced production of IL-1β and TNF-α in human whole blood, with IC50 values of 0.059 μM and 0.59 μM, respectively; meanwhile, this compound shows weak inhibitory activity against total protein synthesis, with an IC50 of 180 μM[1].
CJ-14897 inhibits LPS-induced production of IL-1β and TNF-α in human whole blood, with IC50 values ranging from 0.059 to 2.6 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 377755-95-8
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Molecular Weight 253.25
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Formel C12H15NO5
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SMILES
CC(O[C@@H](C)[C@H](C1=CN=C(C(OC)=O)C=C1)O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CJ-14897 Related Classifications
HY-182630 Related Classifications
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