Dicloxacillin
Based on 3 publication(s) in Google Scholar
Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus.
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- CAS. Nr.: 3116-76-5
- Formel: C19H17Cl2N3O5S
- Molecular Weight:470.33
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Dicloxacillin
MoreAlle Beta-lactamase Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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β-lactam |
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Cell Line
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Type | Value | Description | References |
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| CHO | IC50 |
16.6 μM
Compound: Dicloxacillin
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Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
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[PMID: 23344796] |
| Sf21 | IC50 |
111.1 μM
Compound: Dicloxacillin
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Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
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[PMID: 21965623] |
| Sf21 | IC50 |
69.7 μM
Compound: Dicloxacillin
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Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
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[PMID: 21965623] |
| THP-1 | EC50 |
0.04 mg/L
Compound: DCX
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Antimicrobial activity against Staphylococcus aureus ATCC 25923 infected in human THP-1 cells after 24 hrs
Antimicrobial activity against Staphylococcus aureus ATCC 25923 infected in human THP-1 cells after 24 hrs
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[PMID: 20308386] |
| THP-1 | EC50 |
0.31 mg/L
Compound: DCX
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Antimicrobial activity against Staphylococcus aureus E19977 infected in human THP-1 cells after 24 hrs
Antimicrobial activity against Staphylococcus aureus E19977 infected in human THP-1 cells after 24 hrs
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[PMID: 20308386] |
Dicloxacillin exhibits EC50 values of 0.06 and 0.50 mg/L in ATCC 25923 and E19977, respectively. Dicloxacillin exhibits MIC values of 0.125 and 0.5 mg/L in ATCC 25923 and E19977 with pH 7.4, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female outbred Swiss Webster mice (Murine peritonitis-sepsis model)[3].
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Dosage:125 mg/kg.
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Administration:IV injection, single doses.
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Result:All the mice survived.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 3116-76-5
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Molecular Weight 470.33
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Formel C19H17Cl2N3O5S
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SMILES
O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C3=C(C)ON=C3C4=C(Cl)C=CC=C4Cl)=O)N1C2=O)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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J Exp Med
2026 Mar 2;223(3):e20241287. PMID: 41400657 -
Biomed Res Int
In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Mycobacterium tuberculosis Clinical Isolates. [Abstract]2018 Jul 2:2018:3579832. PMID: 30065936 -
Reinheit & Dokumentation
Verweise
[1]. Miranda-Novales G, et al. In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains. Ann Clin Microbiol Antimicrob. 2006 Oct 12;5:25. [Content Brief]
[2]. Anne Sandberg, et al. Intra- and extracellular activities of dicloxacillin against Staphylococcus aureus in vivo and in vitro. Antimicrob Agents Chemother. 2010 Jun;54(6):2391-400. [Content Brief]
[3]. John Chu, et al. Discovery of MRSA active antibiotics using primary sequence from the human microbiome. Nat Chem Biol. 2016 Dec;12(12):1004-1006. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Dicloxacillin Related Classifications
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