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Art. -Nr.: HY-187660

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rel-Avibactam

Name: rel-Avibactam
Brand: MedChemExpress
SKU: HY-187660
Availability: PreOrder

(Synonyms: rel-NXL-104 free acid; rel-AVE1330A free acid)

rel-Avibactam (rel-NXL-104 free acid) is an isomer of Avibactam (HY-14879). Avibactam is a β-lactamase inhibitor with an IC₅₀ of 8 nM against TEM-1 β-lactamase and an IC₅₀ of 80 nM against P99 β-lactamase. Avibactam exhibits no significant intrinsic antibacterial activity when used alone. Avibactam restores the activity of Ceftazidime (HY-B0593) against β-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. Avibactam does not enhance the activity of Ceftazidime against Acinetobacter spp., Burkholderia spp., or most anaerobic Gram-negative bacilli. Avibactam is used in research related to Gram-negative bacterial infections.

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CAS. Nr.: 396731-14-9
Formel: C₇H₁₁N₃O₆S
Molecular Weight:265.24

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

rel-Avibactam Chemical Structure

CAS. Nr.: 396731-14-9

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Biologische Aktivität

Beschreibung

Alle Beta-lactamase Isoform-spezifische Produkte anzeigen :

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

In Vitro

Bacterial InfectionOthers

Bacterial Infection

Avibactam potently inhibits Ambler class A, class C, and some class D β-lactamases, with a turnover number of 1. It exhibits superior potency to existing β-lactamase inhibitors, with particularly prominent inhibitory activity against the KPC enzyme^[1].
Avibactam (4 μg/mL) significantly enhances the in vitro activity of Ceftazidime (HY-B0593) against Enterobacteriaceae and Pseudomonas aeruginosa (including Ceftazidime-resistant strains), but does not potentiate the activity of Ceftazidime against Acinetobacter baumannii, Burkholderia cepacia, or Stenotrophomonas maltophilia^[1].
Avibactam (4 μg/mL) enhances the in vitro activity of Ceftazidime against Prevotella/Porphyromonas species and Fusobacterium species, but does not enhance the activity of Ceftazidime against most Bacteroides species^[1].

Others

Avibactam (5 min) potently inhibits purified TEM-1 β-lactamase from Escherichia coli (IC₅₀ = 8 nM) and purified P99 β-lactamase from Enterobacter cloacae 293HT6 (IC₅₀ = 80 nM)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS. Nr. 396731-14-9
Molecular Weight 265.24
Formel C₇H₁₁N₃O₆S
SMILES

NC([C@@H]1[N@]2C(N([C@](CC1)([H])C2)OS(=O)(O)=O)=O)=O
Synonyms

rel-NXL-104 free acid; rel-AVE1330A free acid
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Lagacé-Wiens P, et al. Ceftazidime-avibactam: an evidence-based review of its pharmacology and potential use in the treatment of Gram-negative bacterial infections. Core evidence. 2014;9:13-25. [Content Brief]

[2]. Bonnefoy A, et al. In vitro activity of AVE1330A, an innovative broad-spectrum non-beta-lactam beta-lactamase inhibitor. The Journal of antimicrobial chemotherapy. 2004 Aug;54(2):410-7.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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rel-Avibactam

Alle Beta-lactamase Isoform-spezifische Produkte anzeigen

Alle Antibiotic Isoform-spezifische Produkte anzeigen

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rel-Avibactam

Alle Beta-lactamase Isoform-spezifische Produkte anzeigen

Alle Antibiotic Isoform-spezifische Produkte anzeigen

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