Eupalestin
Eupalestin is an anti-inflammatory agent. Eupalestin reduces the levels of p-p65 NF-κB and p-p38 MAPK. Eupalestin inhibits MPO and adenosine deaminase. Eupalestin decreases the levels of pro-inflammatory cytokines including IL-17A, IL-6, TNF and IFN-γ. Eupalestin exerts anti-inflammatory activity in a carrageenan (HY-125474)-induced mouse pleurisy model.
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- CAS. Nr.: 73340-44-0
- Formel: C21H20O9
- Molecular Weight:416.38
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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IL-17A |
IL-6 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss (male, 18-22 g)[1]
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Dosage:2.5 mg/kg; 5 mg/kg; 10 mg/kg
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Administration:i.p.; single dose; 0.5 h pre-carrageenan
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Result:Significantly reduced leukocyte and neutrophil influx, and protein concentration of the pleural exudate at 5 mg/kg and 10 mg/kg (p < 0.01).
Achieved 18.3% inhibition of myeloperoxidase (MPO) concentration at 5 mg/kg (p < 0.05).
Achieved 54.6% inhibition of adenosine deaminase (ADA) concentration at 5 mg/kg (p < 0.01).
Achieved 80.8% inhibition of nitric oxide metabolites (NOx) concentration at 5 mg/kg (p < 0.05).
Significantly reduced levels of pro-inflammatory cytokines interleukin 17A (IL-17A), interleukin 6 (IL-6), tumor necrosis factor (TNF), and interferon gamma (IFN-γ) in pleural exudate at 5 mg/kg (p < 0.05).
Significantly reduced phosphorylation of p65 subunit of NF-κB (p-p65 NF-κB) and p38 mitogen-activated protein kinases (p-p38 MAPK) in lung tissue at 5 mg/kg (p < 0.01).
Chemical Information
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CAS. Nr. 73340-44-0
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Molecular Weight 416.38
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Formel C21H20O9
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SMILES
O=C1C=C(OC2=C(OC)C(OC)=C(OC)C(OC)=C12)C=3C=C(OC)C=4OCOC4C3
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Eupalestin Related Classifications
HY-N8529 Related Classifications
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