Flucopride
Flucopride (Compound 4a) is an AChE inhibitor (IC50: 24 nM), and a partial 5-HT4R agonist (Ki: 9.6 nM for (h)5-HT4R). Flucopride promotes the non-amyloidogenic processing of APP in COS-7 transiently expressing (h)5-HT4R (EC50: 23.0 nM). Flucopride may has good gastrointestinal track (GIT) penetration, and blood-brain barrier (BBB) cross-membrane penetration (PAMPA assay).
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- CAS. Nr.: 1639925-34-0
- Formel: C22H33FN2O2
- Molecular Weight:376.51
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
AChE 24 nM (IC50) |
huamn 5-HT4(c) Receptor 9.6 nM (Ki) |
Chemical Information
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CAS. Nr. 1639925-34-0
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Molecular Weight 376.51
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Formel C22H33FN2O2
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SMILES
O=C(C1=CC(F)=C(N)C=C1OC)CCC2CCN(CC3CCCCC3)CC2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Flucopride Related Classifications
HY-168241 Related Classifications
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