Levemopamil
Levemopamil is a calcium channel blocker and 5-HT2 receptor antagonist. Levemopamil exerts renoprotective effects against ischemic acute kidney injury. Levemopamil is applicable to research related to ischemic acute renal failure.
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- CAS. Nr.: 101238-51-1
- Formel: C23H30N2
- Molecular Weight:334.50
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
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Biologische Aktivität
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (female, adult, 191-239 g, left unilateral renal artery occlusion for 1 hour followed by 6 hours of reperfusion/reflow)[1]
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Dosage:6 mg/kg/h
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Administration:i.v.; continuous infusion; from 1 hour before ischaemia until 6 hours after reflow
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Result:Significantly increased urine flow and maintained measurable endogenous creatinine clearance in the ischaemic left kidney at 2 and 6 h of reperfusion.
Largely preserved mitochondrial ATP synthesis and normal ADP/O ratio.
Slightly attenuated the rise in cortical mitochondrial calcium content.
Chemical Information
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CAS. Nr. 101238-51-1
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Molecular Weight 334.50
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Formel C23H30N2
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SMILES
CN(CCC1=CC=CC=C1)CCC[C@@](C#N)(C2=CC=CC=C2)C(C)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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