Art. -Nr.: HY-N2036

Mosloflavone

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with ?anti-EV71 activity. Mosloflavone? inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.

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Reinheit: 99.92%
CAS. Nr.: 740-33-0
Formel: C₁₇H₁₄O₅
Molecular Weight:298.29

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Mosloflavone Chemical Structure

CAS. Nr.: 740-33-0

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: EV71; bacterial^[1]^[2]

Alle TNF Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
H9	IC₅₀	20.2 μg/mL Compound: 1	Concentration that inhibits uninfected H9 cell growth by 50%. Concentration that inhibits uninfected H9 cell growth by 50%.	[PMID: 12729671]
HT-22	EC₅₀	23.4 μM Compound: 13	Neuroprotective activity against glutamate-induced cell death in mouse HT-22 cells assessed as increase in cell viability after 24 hrs by EZ-Cytox assay Neuroprotective activity against glutamate-induced cell death in mouse HT-22 cells assessed as increase in cell viability after 24 hrs by EZ-Cytox assay	[PMID: 32991171]
J774.A1	IC₅₀	0.22 μM Compound: 46	Anti-inflammatory activity in mouse J774.A1 macrophage cells assessed as reduction in LPS-induced TNF-alpha production Anti-inflammatory activity in mouse J774.A1 macrophage cells assessed as reduction in LPS-induced TNF-alpha production	[PMID: 37683361]
J774.A1	IC₅₀	6.4 μM Compound: 46	Antiinflammatory activity in LPS-induced mouse J774.A1 macrophage cells assessed as reduction in LPS-induced IL-1 beta level Antiinflammatory activity in LPS-induced mouse J774.A1 macrophage cells assessed as reduction in LPS-induced IL-1 beta level	[PMID: 37683361]
KB	IC₅₀	>100 μM Compound: 8	Inhibitory activity against KB cell line after 72 h of drug exposure Inhibitory activity against KB cell line after 72 h of drug exposure	[PMID: 15481991]
KB 3-1	EC₅₀	4.6 μM Compound: 8	Concentration that causes 50% of maximum vinblastine accumulation in KB/MDR cells in 1 h Concentration that causes 50% of maximum vinblastine accumulation in KB/MDR cells in 1 h	[PMID: 15481991]
KB 3-1	IC₅₀	>100 μM Compound: 8	Inhibitory activity against KB/MDR cell line after 72 hr of drug exposure Inhibitory activity against KB/MDR cell line after 72 hr of drug exposure	[PMID: 15481991]
MCF7	IC₅₀	>50 μM Compound: 14	Cytotoxicity against human MCF7 cells after 72 hrs by MTS reduction assay Cytotoxicity against human MCF7 cells after 72 hrs by MTS reduction assay	[PMID: 20704331]
NCI-H460	IC₅₀	>50 μM Compound: 14	Cytotoxicity against human NCI-H460 cells after 72 hrs by MTS reduction assay Cytotoxicity against human NCI-H460 cells after 72 hrs by MTS reduction assay	[PMID: 20704331]
SF-268	IC₅₀	>50 μM Compound: 14	Cytotoxicity against human SF268 cells after 72 hrs by MTS reduction assay Cytotoxicity against human SF268 cells after 72 hrs by MTS reduction assay	[PMID: 20704331]

In Vitro

Mosloflavone shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC₅₀ values of 16.4 uM and 6.4 uM, respectively; inhibits TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A as a dose-dependent manner, it also can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 740-33-0
Appearance Solid
Molecular Weight 298.29
Formel C₁₇H₁₄O₅
Color Light yellow to yellow
SMILES

O=C1C=C(C2=CC=CC=C2)OC3=CC(OC)=C(OC)C(O)=C13
Structure Classification
- Flavonoids
- Flavones
- Phenols
- Monophenols
Initial Source
- Plants
- Labiatae
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Journal Impact Factor

Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (167.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.3524 mL

16.7622 mL

33.5244 mL

5 mM

0.6705 mL

3.3524 mL

6.7049 mL

10 mM

0.3352 mL

1.6762 mL

3.3524 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (8.38 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. 2.Choi HJ, et al. Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71.Biomol Ther (Seoul). 2016 Sep 1;24(5):552-8. [Content Brief]

[2]. 2.Hnamte S, et al. Mosloflavone attenuates the quorum sensing controlled virulence phenotypes and biofilm formation in Pseudomonas aeruginosa PAO1: In vitro, in vivo and in silico approach.Microb Pathog. 2019 Jun;131:128-134. [Content Brief]

[3]. 4.Singh B, et al. Anti-inflammatory and immunomodulatory flavones from Actinocarya tibetica Benth.Nat Prod Res. 2013;27(23):2227-30. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.3524 mL	16.7622 mL	33.5244 mL	83.8111 mL
	5 mM	0.6705 mL	3.3524 mL	6.7049 mL	16.7622 mL
	10 mM	0.3352 mL	1.6762 mL	3.3524 mL	8.3811 mL
	15 mM	0.2235 mL	1.1175 mL	2.2350 mL	5.5874 mL
	20 mM	0.1676 mL	0.8381 mL	1.6762 mL	4.1906 mL
	25 mM	0.1341 mL	0.6705 mL	1.3410 mL	3.3524 mL
	30 mM	0.1117 mL	0.5587 mL	1.1175 mL	2.7937 mL
	40 mM	0.0838 mL	0.4191 mL	0.8381 mL	2.0953 mL
	50 mM	0.0670 mL	0.3352 mL	0.6705 mL	1.6762 mL
	60 mM	0.0559 mL	0.2794 mL	0.5587 mL	1.3969 mL
	80 mM	0.0419 mL	0.2095 mL	0.4191 mL	1.0476 mL
	100 mM	0.0335 mL	0.1676 mL	0.3352 mL	0.8381 mL

Keywords

Mosloflavone

1 Cited Publications

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Mosloflavone

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Publications Citing Use of MedChemExpress (MCE) Mosloflavone

Alle TNF Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Mosloflavone Related Classifications

HY-N2036 Related Classifications