Platycoside E
Based on 2 publication(s) in Google Scholar
Platycoside E is an orally effective saponin. Platycoside E inhibits HDM-induced nuclear translocation and downstream inflammatory signaling, reduces NADPH oxidase expression/activity and ER stress, suppresses intracellular and mitochondrial ROS and proinflammatory cytokine production, and enhances superoxide dismutase activity. Platycoside E can be used in research on cognitive dysfunction, memory impairment, obesity-related asthma, and HDM-induced allergic airway inflammation.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.81%
- CAS. Nr.: 237068-41-6
- Formel: C69H112O38
- Molecular Weight:1549.60
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Platycoside E
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Biologische Aktivität
Beschreibung
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TNF-α |
IL-6 |
IL-1β |
SOD |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:IL-13-stimulated BEAS-2B bronchial epithelial cells
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Concentration:5 and 10 μM
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Incubation Time:24, 48, 72 h
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Result:At 10 μM, viability of IL-13-stimulated BEAS-2B cells was recovered at 48 h; at 72 h, viability was recovered at both 5 and 10 μM.
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Cell Line:IL-13-stimulated BEAS-2B bronchial epithelial cells
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Concentration:5 and 10 μM (1 h pretreatment; IL-13 10 ng/mL)
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Incubation Time:1 h (pretreatment)
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Result:Abolished the IL-13-induced increases in TNF-α, IL-6, and IL-1β in a dose-dependent manner.
In Vivo
Platycoside E (2-10 mg/kg; p.o.; once daily; for 4 consecutive days) ameliorates ethanol-induced memory impairment in mice, with the 10 mg/kg dose significantly prolonging the step-through latency[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (female, 4 weeks of age)[4]
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Dosage:20 mg/kg
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Administration:i.p.; twice weekly during weeks 9 and 10; daily during week 12
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Result:In HFD/OVA obese asthmatic mice, reduced body weight/body-mass change, improved AHR to methacholine, and decreased BALF total cells, macrophages, eosinophils, and neutrophils.
Suppressed TNF-α, IL-1β, IL-6, IL-4, IL-5, IL-13, IL-17, and eotaxin levels in BALF and lung tissues.
Reduced lung inflammation scores and EMBP-positive eosinophil infiltration.
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Animal Model:C57BL/6 (female, 4 weeks of age)[4]
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Dosage:20 mg/kg
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Administration:i.p.; twice weekly during weeks 9 and 10; daily during week 12
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Result:In HFD-fed mice, reduced body weight/body-mass change.
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Animal Model:ICR (male, 18-20 g)[6]
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Dosage:2 mg/kg; 10 mg/kg
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Administration:p.o.; once daily; for 4 consecutive days
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Result:In the test trial, step-through latency was 85.5 s at 2 mg/kg and 280.1 s at 10 mg/kg.
Training-trial step-through latency was 46.6 s at 2 mg/kg and 43.7 s at 10 mg/kg.
Chemical Information
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CAS. Nr. 237068-41-6
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Appearance Solid
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Molecular Weight 1549.60
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Formel C69H112O38
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Color White to off-white
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SMILES
O[C@H]([C@@H]([C@@H](O[C@@]1([H])[C@@H]([C@H]([C@H](O)CO1)O[C@@]2([H])[C@@H]([C@](CO)(O)CO2)O)O)[C@H](C)O3)O)[C@]3([H])O[C@H]([C@H]([C@@H](O)CO4)O)[C@@H]4OC([C@]56[C@](CC(C)(C)CC6)([H])C7=CC[C@@]([C@@]8([C@@](C(CO)([C@@H](O[C@]9([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]9O)CO[C@@H]%10O[C@@H]([C@@H](O)[C@H](O)[C@H]%10O)CO[C@@H]%11O[C@@H]([C@@H](O)[C@H](O)[C@H]%11O)CO)[C@@H](O)C8)CO)([H])CC%12)C)([H])[C@]%12(C)[C@]7(C)C[C@H]5O)=O
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Structure Classification
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Molecules
Characterization of Saponins from Various Parts of Platycodon grandiflorum Using UPLC-QToF/MS. [Abstract]2021 Dec 24;27(1):107. PMID: 35011337 -
Mol Immunol
Platycoside E alleviates allergic airway inflammation in obesity-related asthma mouse model. [Abstract]2023 Oct:162:74-83. PMID: 37659168
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (64.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Reinheit & Dokumentation
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Data Sheet (297 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[2]. Choi JH, et al. Saponins, especially platyconic acid A, from Platycodon grandiflorum reduce airway inflammation in ovalbumin-induced mice and PMA-exposed A549 cells. Journal of agricultural and food chemistry. 2015 Feb 11;63(5):1468-76. [Content Brief]
[4]. Xu S, et al. Platycoside E alleviates allergic airway inflammation in obesity-related asthma mouse model. Molecular immunology. 2023 Oct;162:74-83. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.6453 mL | 3.2266 mL | 6.4533 mL | 16.1332 mL |
| 5 mM | 0.1291 mL | 0.6453 mL | 1.2907 mL | 3.2266 mL | |
| 10 mM | 0.0645 mL | 0.3227 mL | 0.6453 mL | 1.6133 mL | |
| 15 mM | 0.0430 mL | 0.2151 mL | 0.4302 mL | 1.0755 mL | |
| 20 mM | 0.0323 mL | 0.1613 mL | 0.3227 mL | 0.8067 mL | |
| 25 mM | 0.0258 mL | 0.1291 mL | 0.2581 mL | 0.6453 mL | |
| 30 mM | 0.0215 mL | 0.1076 mL | 0.2151 mL | 0.5378 mL | |
| 40 mM | 0.0161 mL | 0.0807 mL | 0.1613 mL | 0.4033 mL | |
| 50 mM | 0.0129 mL | 0.0645 mL | 0.1291 mL | 0.3227 mL | |
| 60 mM | 0.0108 mL | 0.0538 mL | 0.1076 mL | 0.2689 mL |
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