SCR0911
SCR0911 is an inhibitor of mycobacterial cytochrome bcc oxidase and Plasmodium falciparum cytochrome bc1. SCR0911 disrupts oxidative phosphorylation by binding to mycobacterial cytochrome bcc, binds to the Qi site of Plasmodium falciparum cytochrome bc1, inhibits mycobacterial cell growth and ATP synthesis, and exhibits broad-spectrum anti-mycobacterial and anti-malarial activities. SCR0911 can be used in research related to tuberculosis, malaria, and isolated persistent hypermethioninemia (iph).
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- CAS. Nr.: 1379615-30-1
- Formel: C23H17F3N2O3
- Molecular Weight:426.39
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Chemical Information
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- Reinheit & Dokumentation
- Verweise
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Biologische Aktivität
Beschreibung
In Vitro
SCR0911 inhibits the growth of M. smegmatis mc2155 (MIC50 = 272 μM) and M. bovis BCG (MIC50 = 107 μM), but fails to inhibit the growth of the M. smegmatis Δbcc mutant strain, indicating that its growth inhibitory activity depends on a functionally intact cytochrome bcc complex[1].
SCR0911 (24 h) inhibits intracellular ATP synthesis of M. bovis BCG, with an IC50 of 50 μM[1].
SCR0911 (30 min) inhibits ATP synthesis in M. smegmatis IMVs (IC50 = 7.6 μM) and M. bovis BCG IMVs (IC50 = 6.9 μM) when NADH serves as the electron donor[1].
SCR0911 (30 min) inhibits ATP synthesis in M. smegmatis PMVs, with comparable potency when NADH (IC50 = 3.8 μM) or succinate (IC50 = 3.4 μM) serves as the electron donor[1].
SCR0911 (680 μM) completely inhibits oxygen consumption in M. smegmatis mc2155[1].
SCR0911 (10 mM) restores the SAMe-producing activity of purified human MAT-1 MAT-1R264H mutant protein to the wild-type level[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Kinase activity and phosphorylation assays
- Western Blot
- Protocol for Cell Counting and Cell Density Analysis
- Somatic Cell Culture
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Kinase activity and phosphorylation assays
- Cell Counting-Based Growth Curve Assay
- MTT Cell Proliferation Assay
- Cell Viability Determination by MTT Colorimetric Assay
Chemical Information
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CAS. Nr. 1379615-30-1
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Molecular Weight 426.39
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Formel C23H17F3N2O3
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SMILES
O=C1C2=CC=C(C=C2NC(C3=CN=CC(C4=CC=C(C=C4)OC(F)(F)F)=C3)=C1C)OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Chong SMS, et al. Antituberculosis Activity of the Antimalaria Cytochrome bcc Oxidase Inhibitor SCR0911. ACS Infect Dis. 2020;6(4):725-737. [Content Brief]
[2]. Panmanee J, et al. Structural basis of the dominant inheritance of hypermethioninemia associated with the Arg264His mutation in the MAT1A gene. Acta Crystallogr D Struct Biol. 2020;76(Pt 6):594-607. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SCR0911 Related Classifications
HY-182711 Related Classifications
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