Art. -Nr.: HY-N0365

Sennoside A

6 Cited Publications

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Based on 6 publication(s) in Google Scholar

Sennoside A is an anthraquinone glycoside found in senna (Cassia angustifolia). Sennoside A is an HIV-1 inhibitor (IC₅₀=3.8 μM) that inhibits HIV-1 replication. Sennoside A also inhibits HIV-1 reverse transcriptase (RT)-related DNA polymerase (RDDP) and ribonuclease H (Ribonuclease H) with IC₅₀s of 1.9 μM and 5.3 μM, respectively.

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Reinheit: 99.66%
CAS. Nr.: 81-27-6
Formel: C₄₂H₃₈O₂₀
Molecular Weight:862.74

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Sennoside A Chemical Structure

CAS. Nr.: 81-27-6

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (6)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

HIV-1

DNA Polymerase

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

Alle HIV Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	68.2 μM Compound: 7	Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay	[PMID: 17949858]
HepG2	IC₅₀	51.6 μM Compound: 7	Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay	[PMID: 17949858]

In Vitro

Sennoside A inhibits different variants of RDDP and RNase H. Inhibits different variants of RDDP with IC50s of 78 μM (K103N RT), 21.3 μM (Y181C RT), and 64 μM (Y188L RT), respectively. Inhibits different variants of RNase H with IC50s of 18.4 μM (N474A RT) and 17.7 μM (Q475A RT), respectively^[3].
Infects Jurka cells with HIV-1 recombinant CAT virus, which is pseudotyped with the envelope glycoprotein from the HXBc2 laboratory-adapted T-tropic virus. Sennoside A (5-20 μM; 72 h) significantly inhibits CAT activity in infected cell^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sennoside A (25 mg/kg, 50 mg/kg; intragastric gavage for 12 weeks) alters the gut microbiome composition of type 2 diabetes (T2D) mice and mediates anti-obesity effects^[3].
Sennoside A also reduces inflammation and increases tight junction proteins in the ileum of genetically defective mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 81-27-6
Appearance Solid
Molecular Weight 862.74
Formel C₄₂H₃₈O₂₀
Color Light yellow to yellow
SMILES

O=C(C(C=C1[C@@]([C@]2([H])C3=C(C(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC=C3)C(C5=C(O)C=C(C(O)=O)C=C25)=O)([H])C6=C7C(O[C@H]8[C@@H]([C@H]([C@@H]([C@@H](CO)O8)O)O)O)=CC=C6)=CC(O)=C1C7=O)O
Structure Classification
- Quinones
- Anthraquinones
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (6)

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Journal Impact Factor

Int Immunopharmacol

Sennoside A restrains TRAF6 level to modulate ferroptosis, inflammation and cognitive impairment in aging mice with Alzheimer's Disease. [Abstract]

2023 Jul:120:110290. PMID: 37216800
J Enzyme Inhib Med Chem

Natural product sennoside B disrupts liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein by inhibiting its RNA-binding activity. [Abstract]

2025 Dec;40(1):2501743. PMID: 40371698
Naunyn Schmiedebergs Arch Pharmacol

Sennoside A represses the malignant phenotype and tumor immune microenvironment of non-small cell lung cancer cells by inhibiting the TRAF6/NF-κB pathway. [Abstract]

2025 May;398(5):5405-5415. PMID: 39549059
Integr Cancer Ther

Sennoside A Modulates the Ferroptosis and Immune Evasion of Oral Squamous Cell Carcinoma Cells Through Inhibiting the NF-κB Pathway. [Abstract]

2025 Jan-Dec:24:15347354251375464. PMID: 40958203

Sennoside A purchased from MedChemExpress. Usage Cited in: Integr Cancer Ther. 2025 Jan-Dec:24:15347354251375464. [Abstract]

The cell viability was detected by CCK-8 assays after HOK cells were treated with 0, 6.25, 12.5, 25, 50, 100, 200 and 400 μM of Sennoside A (SA) for 48 hours.

Sennoside A purchased from MedChemExpress. Usage Cited in: Integr Cancer Ther. 2025 Jan-Dec:24:15347354251375464. [Abstract]

The relative protein expression of GPX4 and xCT was examined by western blot after SCC7 and CAL27 cells were treated with 25, 50 and 100 μM Sennoside A (SA) for 48 hours.

Sennoside A purchased from MedChemExpress. Usage Cited in: Integr Cancer Ther. 2025 Jan-Dec:24:15347354251375464. [Abstract]

The relative lipid ROS level was examined after SCC7 and CAL27 cells were incubated with 25, 50 and 100 μM Sennoside A (SA) for 48 hours.

Sennoside A purchased from MedChemExpress. Usage Cited in: Integr Cancer Ther. 2025 Jan-Dec:24:15347354251375464. [Abstract]

Measurement of IFN-γ, IL-2 and TNF-α by ELISA incubated with 25, 50 and 100 μM Sennoside A (SA).

Sennoside A purchased from MedChemExpress. Usage Cited in: Integr Cancer Ther. 2025 Jan-Dec:24:15347354251375464. [Abstract]

Pathological examination by HE staining, and the expression levels of GPX4, PD-L1, and IFN-γ in tumor tissues were detected by immunohistochemistry treated with Sennoside A (SA) (10 mg/kg, i.p.).
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
J Mol Histol

Sennoside A alleviates sepsis-triggered acute kidney injury via activating SIRT1 signaling pathway. [Abstract]

2025 Dec 29;57(1):15. PMID: 41460380

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (115.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1591 mL

5.7955 mL

11.5910 mL

5 mM

0.2318 mL

1.1591 mL

2.3182 mL

10 mM

0.1159 mL

0.5795 mL

1.1591 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 6.25 mg/mL (7.24 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 6.25 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (2.41 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Rama Reddy NR, et al. Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non-Model Plant with Potent Laxative Properties. PLoS One. 2015 Jun 22;10(6):e0129422. [Content Brief]

[2]. Esposito F, et al. Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication. Phytomedicine. 2016 Nov 15;23(12):1383-1391. [Content Brief]

[3]. Esposito F, et al. Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication. Phytomedicine. 2016 Nov 15;23(12):1383-1391. [Content Brief]

[4]. Wei Z, et al. Gut Bacteria Selectively Altered by Sennoside A Alleviate Type 2 Diabetes and Obesity Traits. Oxid Med Cell Longev. 2020 Jun 25;2020:2375676. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.1591 mL	5.7955 mL	11.5910 mL	28.9774 mL
	5 mM	0.2318 mL	1.1591 mL	2.3182 mL	5.7955 mL
	10 mM	0.1159 mL	0.5795 mL	1.1591 mL	2.8977 mL
	15 mM	0.0773 mL	0.3864 mL	0.7727 mL	1.9318 mL
	20 mM	0.0580 mL	0.2898 mL	0.5795 mL	1.4489 mL
	25 mM	0.0464 mL	0.2318 mL	0.4636 mL	1.1591 mL
	30 mM	0.0386 mL	0.1932 mL	0.3864 mL	0.9659 mL
	40 mM	0.0290 mL	0.1449 mL	0.2898 mL	0.7244 mL
	50 mM	0.0232 mL	0.1159 mL	0.2318 mL	0.5795 mL
	60 mM	0.0193 mL	0.0966 mL	0.1932 mL	0.4830 mL
	80 mM	0.0145 mL	0.0724 mL	0.1449 mL	0.3622 mL
	100 mM	0.0116 mL	0.0580 mL	0.1159 mL	0.2898 mL

Keywords

Sennoside A

6 Cited Publications

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Sennoside A

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Publications Citing Use of MedChemExpress (MCE) Sennoside A

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Alle HIV Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (6)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Sennoside A Related Classifications

HY-N0365 Related Classifications