STAT6 degrader-3
Based on 1 Customer Validation
STAT6 degrader-3 is a potent, bifunctional STAT6 degrader that recruits STAT6 to an E3 ubiquitin ligase, promoting STAT6 ubiquitination and subsequently inducing its degradation. STAT6 degrader-3 can be used in research concerning STAT6-related inflammation and immune signaling.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.26%
- CAS. Nr.: 3077464-19-5
- Formel: C47H53N11O5
- Molecular Weight:851.99
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
STAT6 <1 nM (DC50) |
In Vitro
STAT6 degrader-3 (compound I-2) (24 h) induces STAT6 degradation in an A549 cell STAT6 MSD degradation assay, with a DC50 <1 nM and Dmax >90%[1].
STAT6 degrader-3 (up to 10 μM; 10-dose, 4-fold dilution series; 24 h) induces STAT6 degradation in A549 cells with endogenous STAT6-HiBiT tagging, with a HiBiT degradation DC50 <1 nM and Dmax >90%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3077464-19-5
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Appearance Solid
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Molecular Weight 851.99
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Formel C47H53N11O5
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Color White to off-white
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SMILES
O=C(N(C)C)C1=CC2=C(C3=CC=C(N4CCN(CCCC5=CC=C6C(N(C)C(N6C7C(NC(CC7)=O)=O)=O)=C5)CC4)C=C3)C=C(C8=CCCN(C8)C(CCN9N=NC=C9)=O)C=C2N1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (117.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (2.93 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (2.93 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.1737 mL | 5.8686 mL | 11.7372 mL | 29.3431 mL |
| 5 mM | 0.2347 mL | 1.1737 mL | 2.3474 mL | 5.8686 mL | |
| 10 mM | 0.1174 mL | 0.5869 mL | 1.1737 mL | 2.9343 mL | |
| 15 mM | 0.0782 mL | 0.3912 mL | 0.7825 mL | 1.9562 mL | |
| 20 mM | 0.0587 mL | 0.2934 mL | 0.5869 mL | 1.4672 mL | |
| 25 mM | 0.0469 mL | 0.2347 mL | 0.4695 mL | 1.1737 mL | |
| 30 mM | 0.0391 mL | 0.1956 mL | 0.3912 mL | 0.9781 mL | |
| 40 mM | 0.0293 mL | 0.1467 mL | 0.2934 mL | 0.7336 mL | |
| 50 mM | 0.0235 mL | 0.1174 mL | 0.2347 mL | 0.5869 mL | |
| 60 mM | 0.0196 mL | 0.0978 mL | 0.1956 mL | 0.4891 mL | |
| 80 mM | 0.0147 mL | 0.0734 mL | 0.1467 mL | 0.3668 mL | |
| 100 mM | 0.0117 mL | 0.0587 mL | 0.1174 mL | 0.2934 mL |
STAT6 degrader-3 Related Classifications
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