Art. -Nr.: HY-B1794

Thiethylperazine

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Thiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects.

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Reinheit: 99.91%
CAS. Nr.: 1420-55-9
Formel: C₂₂H₂₉N₃S₂
Molecular Weight:399.62

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Thiethylperazine Chemical Structure

CAS. Nr.: 1420-55-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

D₂ Receptor

H₁ Receptor

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen :

Alle Histamine Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

Thiethylperazine can enhance the antibiotic (Vancomycin) activity at a concentration as low as 2 μg/mL. Thiethylperazine inhibits Vancomycin-sensitive E. faecalis ATCC 29212, Vancomycin-resistant E. faecalis ATCC 51299 and vancomycin-resistant E. faecalis (VREF) isolates with MIC values of 8 μg/mL, 16 μg/mL and 8 μg/mL, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Thiethylperazine (3 mg/kg; intramuscular injection; twice daily; for 30 days) significantly reduces Aβ42 levels in young APP/PS1 mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Young Aβ precursor protein (APPswe) and mutant presenilin-1 (PS1) (APP/PS1) mice^[2]
Dosage:

3 mg/kg
Administration:

Intramuscular injection; twice daily; for 30 days
Result:

Significantly reduced Aβ42 levels in APP/PS1 mice.

Chemical Information

CAS. Nr. 1420-55-9
Appearance Solid
Molecular Weight 399.62
Formel C₂₂H₂₉N₃S₂
Color Light brown to gray
SMILES

CN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(SCC)C=C24)CC1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (3)

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Journal Impact Factor

J Adv Res

The gut microbiotas with metabolites regulate the protective role of miR-30a-5p in myocardial infarction. [Abstract]

2024 Oct 21:S2090-1232(24)00472-7. PMID: 39442873
ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (250.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5024 mL

12.5119 mL

25.0238 mL

5 mM

0.5005 mL

2.5024 mL

5.0048 mL

10 mM

0.2502 mL

1.2512 mL

2.5024 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Czeizel AE, et al. Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drug. BJOG. 2003 May;110(5):497-9. [Content Brief]

[2]. Krohn M, et al. Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice. J Clin Invest. 2011 Oct;121(10):3924-31. [Content Brief]

[3]. Rahbar M, et al. Enhancement of vancomycin activity by phenothiazines against vancomycin-resistant Enterococcus faecium in vitro. Basic Clin Pharmacol Toxicol. 2010 Aug;107(2):676-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5024 mL	12.5119 mL	25.0238 mL	62.5594 mL
	5 mM	0.5005 mL	2.5024 mL	5.0048 mL	12.5119 mL
	10 mM	0.2502 mL	1.2512 mL	2.5024 mL	6.2559 mL
	15 mM	0.1668 mL	0.8341 mL	1.6683 mL	4.1706 mL
	20 mM	0.1251 mL	0.6256 mL	1.2512 mL	3.1280 mL
	25 mM	0.1001 mL	0.5005 mL	1.0010 mL	2.5024 mL
	30 mM	0.0834 mL	0.4171 mL	0.8341 mL	2.0853 mL
	40 mM	0.0626 mL	0.3128 mL	0.6256 mL	1.5640 mL
	50 mM	0.0500 mL	0.2502 mL	0.5005 mL	1.2512 mL
	60 mM	0.0417 mL	0.2085 mL	0.4171 mL	1.0427 mL
	80 mM	0.0313 mL	0.1564 mL	0.3128 mL	0.7820 mL
	100 mM	0.0250 mL	0.1251 mL	0.2502 mL	0.6256 mL

Thiethylperazine

3 Cited Publications

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Thiethylperazine

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Publications Citing Use of MedChemExpress (MCE) Thiethylperazine

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen

Alle Histamine Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (3)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Thiethylperazine Related Classifications

HY-B1794 Related Classifications