VU0477886
VU0477886 is a metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator with potent activating activity on mGlu4 (EC50 = 95nM, 89% Glu Max), good pharmacokinetic characteristics (brain: plasma Kp = 1.3), and significant therapeutic efficacy in Parkinson's disease models.
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- CAS. Nr.: 1926222-30-1
- Formel: C20H13ClN4O3
- Molecular Weight:392.80
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
0.095 nM
Compound: 17a; VU0477886
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Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay
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[PMID: 27131990] |
Chemical Information
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CAS. Nr. 1926222-30-1
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Molecular Weight 392.80
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Formel C20H13ClN4O3
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SMILES
O=C(C1=NC=CC=C1N)NC2=CC=C(N3C(C4=C(C3=O)C=CC=C4)=O)C(Cl)=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
VU0477886 Related Classifications
HY-115796 Related Classifications
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