VU6010572
Based on 1 publication(s) in Google Scholar
VU6010572 is a potent, selective and brain-penetrant mGlu3 negative allosteric modulator with IC50 of 245 nM. VU6010572 is highly CNS penetrant.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.88%
- CAS. Nr.: 2126784-39-0
- Formel: C20H18FNO3
- Molecular Weight:339.36
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Speicherung:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
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Help & FAQs
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GPCR/G Protein Compound Library
HY-L006
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Neuronal Signaling Compound Library
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CNS-Penetrant Compound Library
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Neurotransmitter Receptor Compound Library
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Membrane Protein-targeted Compound Library
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Membrane Receptor-targeted Compound Library
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Allosteric Modulators (AMs) Compound Library
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Publications Citing Use of MedChemExpress (MCE) VU6010572
More
Biologische Aktivität
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mGluR3 245 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
245 nM
Compound: 4; VU6010572
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Negative allosteric modulation of rat mGlu3R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobilization preincubated for 2.5 mins followed by glutamate addition by S3 Fluo-4-AM dye based fluorescence as
Negative allosteric modulation of rat mGlu3R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobilization preincubated for 2.5 mins followed by glutamate addition by S3 Fluo-4-AM dye based fluorescence as
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[PMID: 31358468] |
Chemical Information
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CAS. Nr. 2126784-39-0
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Appearance Solid
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Molecular Weight 339.36
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Formel C20H18FNO3
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Color Off-white to light yellow
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SMILES
O=C1C=C(OC[C@@H](OC2=CC=CC=C2)C)C=CN1C3=CC=C(F)C=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Brain Res Bull
Metabotropic glutamate receptor 1-mediated Ca2+ response is potentiated by activation of metabotropic glutamate receptor 3 in the rat hippocampal marginal zone. [Abstract]2025 Oct 15:231:111535. PMID: 40907773
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (294.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9467 mL | 14.7336 mL | 29.4672 mL | 73.6681 mL |
| 5 mM | 0.5893 mL | 2.9467 mL | 5.8934 mL | 14.7336 mL | |
| 10 mM | 0.2947 mL | 1.4734 mL | 2.9467 mL | 7.3668 mL | |
| 15 mM | 0.1964 mL | 0.9822 mL | 1.9645 mL | 4.9112 mL | |
| 20 mM | 0.1473 mL | 0.7367 mL | 1.4734 mL | 3.6834 mL | |
| 25 mM | 0.1179 mL | 0.5893 mL | 1.1787 mL | 2.9467 mL | |
| 30 mM | 0.0982 mL | 0.4911 mL | 0.9822 mL | 2.4556 mL | |
| 40 mM | 0.0737 mL | 0.3683 mL | 0.7367 mL | 1.8417 mL | |
| 50 mM | 0.0589 mL | 0.2947 mL | 0.5893 mL | 1.4734 mL | |
| 60 mM | 0.0491 mL | 0.2456 mL | 0.4911 mL | 1.2278 mL | |
| 80 mM | 0.0368 mL | 0.1842 mL | 0.3683 mL | 0.9209 mL | |
| 100 mM | 0.0295 mL | 0.1473 mL | 0.2947 mL | 0.7367 mL |
VU6010572 Related Classifications
HY-122138 Related Classifications
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