Art. -Nr.: HY-138364

YUM70

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC₅₀ of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also has in vivo efficacy in a pancreatic cancer xenograft model.

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Reinheit: 98.01%
CAS. Nr.: 423145-35-1
Formel: C₂₁H₁₉ClN₂O₄
Molecular Weight:398.84

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

YUM70 Chemical Structure

CAS. Nr.: 423145-35-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Grp78

Alle HSP Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.8 μM Compound: 21; YUM70	Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 37690265]
BXPC-3	IC₅₀	9.6 μM Compound: 21; YUM70	Cytotoxicity against human BXPC-3 cells assessed as inhibition of cell proliferation incubated for 4 hrs by MTS assay Cytotoxicity against human BXPC-3 cells assessed as inhibition of cell proliferation incubated for 4 hrs by MTS assay	[PMID: 37690265]
MCF7	IC₅₀	2.8 μM Compound: 21; YUM70	Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 37690265]
MIA PaCa-2	IC₅₀	2.8 μM Compound: 21; YUM70	Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay	[PMID: 37690265]
NCI-H1299	IC₅₀	2.8 μM Compound: 21; YUM70	Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37690265]
OVCAR-3	IC₅₀	2.8 μM Compound: 21; YUM70	Antiproliferative activity against human OVCAR-3 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human OVCAR-3 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 37690265]
OVCAR-8	IC₅₀	2.8 μM Compound: 21; YUM70	Antiproliferative activity against human OVCAR-8 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human OVCAR-8 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 37690265]
PANC-1	IC₅₀	4.5 μM Compound: 21; YUM70	Cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay Cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay	[PMID: 37690265]
SH-SY5Y	IC₅₀	2.8 μM Compound: 21; YUM70	Antiproliferative activity against human SH-SY5Y cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human SH-SY5Y cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 37690265]
SK-OV-3	IC₅₀	2.8 μM Compound: 21; YUM70	Antiproliferative activity against human SK-OV-3 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human SK-OV-3 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 37690265]

In Vitro

YUM70 shows selective cytotoxicity for MIA PaCa-2, PANC-1, BxPC-3 cells (IC₅₀=2.8, 4.5, and 9.6 μM, respectively) over normal pancreatic tissue-derived HPNE cells (IC₅₀>30 μM)^[1].
YUM70 (5 μM; 24 h) induces endoplasmic reticulum (ER) stress-mediated apoptosis of MIA PaCa-2cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MIA PaCa-2, PANC-1 cells
Concentration:

0.1, 1, 2.5, 5, 10 μM
Incubation Time:

2, 4, 8, 24, 48 hours
Result:

Increased the protein levels of FAM129A, DDIT3, CHAC-1, DDIT4, UPP1, and GRP78 in a dose- and time-dependent manner.

In Vivo

YUM70 (30 mg/kg; i.p. 5 days a week for 7 weeks) inhibits tumor growth in a MIA PaCa-2 xenograft model^[1].
YUM70 (15 mg/kg; i.v.) exhibits t_1/2 (1.40 h), CL (724.04 mL/h/kg), and V_ss (1162.73 mL/kg) in mice^[1].
YUM70 (30 mg/kg; p.o.) exhibits bioavailability (6.71%), t_1/2 (2.74 h), and CL (9230.15 mL/h/kg) in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

8-week old female NCr nude mice were injected with MIA PaCa-2 cells^[1]
Dosage:

30 mg/kg
Administration:

I.p. 5 days a week for 7 weeks
Result:

Observed a significant tumor growth delay with no significant change in body weight during the course of treatment.

Chemical Information

CAS. Nr. 423145-35-1
Appearance Solid
Molecular Weight 398.84
Formel C₂₁H₁₉ClN₂O₄
Color White to off-white
SMILES

CCCC(NC(C1=CC=C(OCO2)C2=C1)C3=CC(Cl)=C4C=CC=NC4=C3O)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (4)

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Journal Impact Factor

Mol Biomed

Death-associated protein kinase 2 (DAPK2) propagates endoplasmic reticulum stress in macrophages to worsen sepsis through HSPA5-IRE1α axis. [Abstract]

2026 Jun 23;7(1):94. PMID: 42334722
EMBO Mol Med

NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5. [Abstract]

2023 Nov 8;15(11):e17761. PMID: 37807968
Mol Cancer Ther

Unfolded Protein Response as a Therapeutic Target: 4-(Heptyloxy)phenol Induces Programmed Cell Death in Ewing Sarcoma. [Abstract]

2026 Feb 11. PMID: 41670299
Research Square Preprint

2024 Oct 10.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (250.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5073 mL

12.5364 mL

25.0727 mL

5 mM

0.5015 mL

2.5073 mL

5.0145 mL

10 mM

0.2507 mL

1.2536 mL

2.5073 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.5 mg/mL (6.27 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Samanta S, et, al. The hydroxyquinoline analog YUM70 inhibits GRP78 to induce ER stress-mediated apoptosis in pancreatic cancer. Cancer Res. 2021 Feb 2;canres.1540.2020. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5073 mL	12.5364 mL	25.0727 mL	62.6818 mL
	5 mM	0.5015 mL	2.5073 mL	5.0145 mL	12.5364 mL
	10 mM	0.2507 mL	1.2536 mL	2.5073 mL	6.2682 mL
	15 mM	0.1672 mL	0.8358 mL	1.6715 mL	4.1788 mL
	20 mM	0.1254 mL	0.6268 mL	1.2536 mL	3.1341 mL
	25 mM	0.1003 mL	0.5015 mL	1.0029 mL	2.5073 mL
	30 mM	0.0836 mL	0.4179 mL	0.8358 mL	2.0894 mL
	40 mM	0.0627 mL	0.3134 mL	0.6268 mL	1.5670 mL
	50 mM	0.0501 mL	0.2507 mL	0.5015 mL	1.2536 mL
	60 mM	0.0418 mL	0.2089 mL	0.4179 mL	1.0447 mL
	80 mM	0.0313 mL	0.1567 mL	0.3134 mL	0.7835 mL
	100 mM	0.0251 mL	0.1254 mL	0.2507 mL	0.6268 mL

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YUM70

Endoplasmic Reticulum Stress Compound Library

Cytoskeleton Compound Library

Anti-Pancreatic Cancer Compound Library

Cuproptosis Compound Library

Heterocyclic Compound Library

Metabolic Enzyme Compound Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Cell Death Library

Bioactive Compound Library Max

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Publications Citing Use of MedChemExpress (MCE) YUM70

Alle HSP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (4)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

YUM70

Endoplasmic Reticulum Stress Compound Library

Cytoskeleton Compound Library

Anti-Pancreatic Cancer Compound Library

Cuproptosis Compound Library

Heterocyclic Compound Library

Metabolic Enzyme Compound Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Cell Death Library

Bioactive Compound Library Max

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Publications Citing Use of MedChemExpress (MCE) YUM70

Alle HSP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (4)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

YUM70 Related Classifications

HY-138364 Related Classifications