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Cat. No.: HY-124585

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Y08060

Y08060 is a selective BET inhibitor. Y08060 inhibits the viability of C4-2B and LNCaP cell lines with IC₅₀ values of 3.23 and 4.41 μM. Y08060 can suppress colony formation as well as AR expression in prostate cancer cell line. Y08060 can be studied in prostate cancer research.

For research use only. We do not sell to patients.

CAS No.: 2222565-19-5
Formula: C₁₈H₁₉BrN₂O₆S
Molecular Weight:471.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Y08060 Chemical Structure

CAS No.: 2222565-19-5

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Biological Activity
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- Cellular Effect
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Biological Activity

Description

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Cellular Effect

Cell Line	Type	Value	Description	References
CWR22R	IC₅₀	3.38 μM Compound: 36	Antiproliferative activity against human 22Rv1 cells after 96 hrs by Cell-Titer glo reagent based luminescence assay Antiproliferative activity against human 22Rv1 cells after 96 hrs by Cell-Titer glo reagent based luminescence assay	[PMID: 29541371]
DU-145	IC₅₀	23.19 μM Compound: 36	Antiproliferative activity against human DU145 cells after 96 hrs by Cell-Titer glo reagent based luminescence assay Antiproliferative activity against human DU145 cells after 96 hrs by Cell-Titer glo reagent based luminescence assay	[PMID: 29541371]
LNCaP	IC₅₀	4.41 μM Compound: 36	Antiproliferative activity against human LNCAP cells after 96 hrs by Cell-Titer glo reagent based luminescence assay Antiproliferative activity against human LNCAP cells after 96 hrs by Cell-Titer glo reagent based luminescence assay	[PMID: 29541371]
LNCaP C4-2B	IC₅₀	3.23 μM Compound: 36	Antiproliferative activity against human C4-2B cells after 96 hrs by Cell-Titer glo reagent based luminescence assay Antiproliferative activity against human C4-2B cells after 96 hrs by Cell-Titer glo reagent based luminescence assay	[PMID: 29541371]
PC-3	IC₅₀	17.22 μM Compound: 36	Antiproliferative activity against human PC3 cells after 96 hrs by Cell-Titer glo reagent based luminescence assay Antiproliferative activity against human PC3 cells after 96 hrs by Cell-Titer glo reagent based luminescence assay	[PMID: 29541371]

Chemical Information

CAS No. 2222565-19-5
Molecular Weight 471.32
Formula C₁₈H₁₉BrN₂O₆S
SMILES

O=C1NC2=CC(OC)=C(NS(=O)(C3=CC(Br)=CC=C3OC)=O)C=C2OC1(C)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiang, Q., et al., (2018). Y08060: A Selective BET Inhibitor for Treatment of Prostate Cancer. ACS medicinal chemistry letters, 9(3), 262-267. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Y08060

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Biological Activity

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Y08060 Related Classifications

HY-124585 Related Classifications