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Nocodazole

(Synonyms: Oncodazole; R17934)
128 Cited Publications
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Based on 128 publication(s) in Google Scholar

Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.

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  • Pureté: 99.59%
  • CAS No.: 31430-18-9
  • Formule: C14H11N3O3S
  • Masse moléculaire:301.32
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Nocodazole Chemical Structure
    Nocodazole Chemical Structure
  • Experimental Validation Results for Nocodazole
  • Experimental Validation Results for Nocodazole
  • Experimental Validation Results for Nocodazole
  • Experimental Validation Results for Nocodazole
  • Experimental Validation Results for Nocodazole
  • Experimental Validation Results for Nocodazole
  • Experimental Validation Results for Nocodazole
  • Experimental Validation Results for Nocodazole
  • Experimental Validation Results for Nocodazole
  • Experimental Validation Results for Nocodazole
  • Experimental Validation Results for Nocodazole
  • Experimental Validation Results for Nocodazole
CAS No.: 31430-18-9
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  • Nocodazole Chemical Structure
    Nocodazole Chemical Structure
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    Nocodazole purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2024 Dec 18;12(12):e009444. [Abstract]

    Customer Validation
     Immunoblotting of whole cell lysates (WCL) derived from H292 and H1299 cells synchronized in M phase by Nocodazole (200 ng/mL; 16 h) followed by releasing back into cell cycle.

  • 1/16

    Nocodazole purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Dec;11(45):e2405441. [Abstract]

    Customer Validation
     Immunoblot (IB) analysis of WCL derived from T24 and 5637 cells treated with different concentration of nocodazole (150, 300 and 900 nM) for 24 h. g‐i) IB analysis of WCL derived from mice bladder

  • 1/16

    Nocodazole purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Oct 23:e2401842. [Abstract]

    Customer Validation
     Representative immunofluorescent images of α‐tubulin network in Calu‐1 cells at 24 h after CAP treatment with or without Nocodazole (5 µm) treatment. Scale bar, 100 µm.

  • 1/16

    Nocodazole purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 May 26;14(1):3050. [Abstract]

    Customer Validation
     Westernblot analysis of TRABID mRNA and protein levels in HeLa cells treated with 10 μM Lovastatin, 2 μg/ml Aphidicolin, 10 μM RO-3306, or 3 μM Nocodazole for 18 h.

  • 1/16

    Nocodazole purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 May 26;14(1):3050. [Abstract]

    Customer Validation
     RT-qPCR analysis of TRABID mRNA and protein levels in HeLa cells treated with 10 μM Lovastatin, 2 μg/ml Aphidicolin, 10 μM RO-3306, or 3 μM Nocodazole for 18 h.

  • 1/16

    Nocodazole purchased from MedChemExpress. Usage Cited in: Science. 2022 Nov 18;378(6621):eabq7361. [Abstract]

    Customer Validation
     Representative time-lapse images (z-stack) showing microtubule nucleation after nocodazole washout in live human oocytes. Gray, microtubules (GFP-MAP4); magenta, kinetochores (mScarlet-CENPB).
    Flow diagram shows the sequence of experiments. Arrow indicates timelapse imaging initiation. Time is given as hours: minutes after nocodazole washout.

  • 1/16

    Nocodazole purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Oct 12;13(1):6004. [Abstract]

    Customer Validation
     HEK293T cells were transfected with indicated plasmids. Eight hours later, cells were incubated with 1 μM nocodazole overnight with or without 100 μM 2-BP, washed twice with PBS, and incubated in a fresh medium for another 0.5 h. On day 0, WT or 9CS EGFR-HA-SBP was transfected with Streptavidin-Golgin-84 into HEK293T. On day 1, cells were washed with PBS and crosslinked with 2 mM DSP on ice for 2 h, which was stopped by 0.1 M Tris (pH 8.0).

  • 1/16

    Nocodazole purchased from MedChemExpress. Usage Cited in: Autophagy. 2021 Dec;17(12):3976-3991. [Abstract]

    Customer Validation
     Immunoblot of cell lysates and anti-LC3B immunoprecipitates from U2OS cells in the absence or presence of NDZ (Nocodazole) (300 nM) treatment for 24 h followed by 24-h recovery, and cells were left untreated or treated with CQ (40 μM) treatment 8 h prior to harvesting.

  • 1/16

    Nocodazole purchased from MedChemExpress. Usage Cited in: Autophagy. 2021 Dec;17(12):3976-3991. [Abstract]

    Customer Validation
     Immunofluorescent assay showing LC3B and micronuclei of WT and CGAS−/- U2OS cells left untreated or treated with NDZ (300 nM) for 24 h followed by 48-h recovery

  • 1/16

    Nocodazole purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2020 Jun 17;7(15):1903583. [Abstract]

    Customer Validation
     Fluorescence imaging of LNCaP cells treated with the F-actin inhibitor cytoskeleton B (CB), microtubule inhibitor nocodazole (NO), FAK inhibitor PF573288 (PF), ROCK inhibitor Y-27632 (Y), and myosin II (Myo-II) inhibitor (-)-blebbistatin ((-)Bl). After the cells were cultured on different substrates for 3 days, inhibitors were added and incubated for 24 h. (green, F-actin; scale bar, 25 µm).

  • 1/16

    Nocodazole purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2020 Jun 17;7(15):1903583. [Abstract]

    Customer Validation
     Expression of CTC cluster-related (plakoglobin and CD44) and EMT-related (vimentin and E-cadherin, 4 days) proteins in LNCaP cells grown on different substrates after treatment with different inhibitors (Cytoskeleton B (CB), Nocodazole (NO), PF-573288 (PF), Y-27632 (Y), and (-)-Blebbistatin ((-) Bl)).

  • 1/16

    Nocodazole purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Jun 28;10(1):2860. [Abstract]

    Customer Validation
     Immunoblots showing cyclin profiles as well as DEDD expression of control plasmid or ∆NLS-DEDD-overexpressed normal mammary epithelial cells (KTB-37) at different time points after cells withdrawn from nocodazole treatment (100 ng/mL).

  • Nocodazole