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Carlumab

(Synonyms: CNTO 888)
5 Cited Publications
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Based on 5 publication(s) in Google Scholar

Carlumab (CNTO 888) is a human anti-CCL2 (chemokine ligand 2) monoclonal antibody. Carlumab binds to human CCL2 and neutralizes its pro-fibrotic activity. Carlumab inhibits tumor growth by reducing macrophage infiltration and decreasing tumor microvessel density. Carlumab can be used in cancer research, such as prostate cancer.

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  • Pureté : 97.80%
  • CAS No.: 915404-94-3
  • Masse moléculaire:144.87 kDa
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    Shipping with dry ice

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Carlumab
  • Experimental Validation Results for Carlumab
  • Experimental Validation Results for Carlumab
  • Carlumab Chemical Structure
    Carlumab Chemical Structure
CAS No.: 915404-94-3
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized MCP-1/CCL2 Protein, Human (HY-P7237) can bind Carlumab. The EC50 for this effect is 9.459 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5X106 RAW264.7 cells treated with 100ng/mL LPS for 4 hours add 1μg/mL BFA for3 hours with Carlumab (HY-P99188, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃, Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control，cells without incubation with primary antibody were used as the unlabeled control (black).

  • Carlumab Chemical Structure
    1/16
  • Carlumab
  • Immobilized MCP-1/CCL2 Protein, Human (HY-P7237) can bind Carlumab. The EC50 for this effect is 9.459 ng/mL.
  • Flow cytometric analysis of 1.5X106 RAW264.7 cells treated with 100ng/mL LPS for 4 hours add 1μg/mL BFA for3 hours with Carlumab (HY-P99188, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃, Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control，cells without incubation with primary antibody were used as the unlabeled control (black).