Coumaran
Based on 2 publication(s) in Google Scholar
Coumaran (2,3-Dihydrobenzofuran) is an AChE inhibitor with antileishmanial activity. Coumaran may acquire antiparasitic capabilities through activation of macrophages and exert immunomodulatory activity. Coumaran can be used as a biopesticide..
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- Pureté: 99.52%
- CAS No.: 496-16-2
- Formule: C8H8O
- Masse moléculaire:120.15
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Stockage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
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Publications Citing Use of MedChemExpress (MCE) Coumaran
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Activité biologique
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AChE |
Coumaran is active against promastigote (IC50=1.042 μM) and amastigote (IC50=1.43 μM) forms, demonstrating potent antileishmanial activity [2].
Coumaran (0.5-13 μM; 48 h) Not significantly cytotoxic to macrophages or erythrocytes [2].
Coumaran (0.5-13 μM; 24 h) increases phagocyte and lysosomal activity and nitrite (NO2- ) level [2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Promastigotes
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Concentration:0.4, 0.8 and 1.6 µM
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Incubation Time:48 h
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Result:Demonstrated a concentration-dependent reduction in infection of macrophages by 7.0, 22.0 and 33.34% for 0.4, 0.8 and 1.6 µM, respectively.
Chemical Information
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CAS No. 496-16-2
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Appearance Liquid (Density: 1.065 g/cm3)
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Masse moléculaire 120.15
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Formule C8H8O
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Color Colorless to light yellow
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SMILES
C12=CC=CC=C1CCO2
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Synonyms
2,3-Dihydrobenzofuran
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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PLoS Biol
2024 Jun 27;22(6):e3002672. PMID: 38935621 -
bioRxiv
An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence in C. elegans. [Abstract]2024 Apr 3:2023.06.02.542933. PMID: 37333363
Solvant et solubilité
H2O : 150 mg/mL (1248.44 mM; Need ultrasonic)
DMSO : 150 mg/mL (1248.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 3.75 mg/mL (31.21 mM); Clear solution
This protocol yields a clear solution of ≥ 3.75 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (37.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 3.75 mg/mL (31.21 mM); Clear solution
This protocol yields a clear solution of ≥ 3.75 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (37.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (832.29 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureté et documentation
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Fiche technique (280 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Yallappa Rajashekar, et al. Acetylcholinesterase Inhibition by Biofumigant (Coumaran) From Leaves of Lantana Camara in Stored Grain and Household Insect Pests. Biomed Res Int. 2014;2014:187019. [Content Brief]
[2]. de Castro Oliveira LG, et al. In Vitro Effects of the Neolignan 2,3-Dihydrobenzofuran Against Leishmania Amazonensis. Basic Clin Pharmacol Toxicol. 2017 Jan;120(1):52-58. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 8.3229 mL | 41.6146 mL | 83.2293 mL | 208.0732 mL |
| 5 mM | 1.6646 mL | 8.3229 mL | 16.6459 mL | 41.6146 mL | |
| 10 mM | 0.8323 mL | 4.1615 mL | 8.3229 mL | 20.8073 mL | |
| 15 mM | 0.5549 mL | 2.7743 mL | 5.5486 mL | 13.8715 mL | |
| 20 mM | 0.4161 mL | 2.0807 mL | 4.1615 mL | 10.4037 mL | |
| 25 mM | 0.3329 mL | 1.6646 mL | 3.3292 mL | 8.3229 mL | |
| 30 mM | 0.2774 mL | 1.3872 mL | 2.7743 mL | 6.9358 mL | |
| 40 mM | 0.2081 mL | 1.0404 mL | 2.0807 mL | 5.2018 mL | |
| 50 mM | 0.1665 mL | 0.8323 mL | 1.6646 mL | 4.1615 mL | |
| 60 mM | 0.1387 mL | 0.6936 mL | 1.3872 mL | 3.4679 mL | |
| 80 mM | 0.1040 mL | 0.5202 mL | 1.0404 mL | 2.6009 mL | |
| 100 mM | 0.0832 mL | 0.4161 mL | 0.8323 mL | 2.0807 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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