FS102
FS102 is a selective Fc fragment with antigen binding (Fcab) that targets HER2 with a KD value of 0.8 nM. FS102 induces the degradation of HER2, activates Caspase 3/7 and disrupts the integrity of the cell membrane, triggering apoptosis of tumor cells. FS102 is promising for research of cancers such as breast cancer, gastric cancer, and colorectal cancer.
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Human
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Caspase 3 |
Caspase-7 |
HER2 0.8 nM (Kd) |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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SMILES
FS(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)(S(=S)([S](=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S
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Synonyms
BMS-986186
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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