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Itepekimab

(Synonyms: REGN-3500; SAR-440340)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Itepekimab (REGN-3500) is an IgG4 monoclonal antibody against IL-33. Itepekimab reduced airway inflammation and related tissue damage in preliminary clinical studies. Itepekimab has potential effects in asthma, chronic obstructive pulmonary disease (COPD), and atopic dermatitis (AD).

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  • Pureté: 99.496%
  • CAS No.: 2226742-52-3
  • Masse moléculaire:144.64 kDa
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Itepekimab
  • Experimental Validation Results for Itepekimab
  • Experimental Validation Results for Itepekimab
  • Itepekimab Chemical Structure
    Itepekimab Chemical Structure
CAS No.: 2226742-52-3
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[email protected] [email protected]
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized IL-33 Protein, Human (His, HY-P70475) can bind Itepekimab. The EC50 for this effect is 157.7 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 HUVEC cells with Itepekimab (HY-P99673, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Itepekimab Chemical Structure
    1/16
  • Itepekimab
  • Immobilized IL-33 Protein, Human (His, HY-P70475) can bind Itepekimab. The EC50 for this effect is 157.7 ng/mL.
  • Flow cytometric analysis of 1.5×106 HUVEC cells with Itepekimab (HY-P99673, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).