Moracin G
Moracin G is a plant-derived kinase modulator and receptor ligand that forms stable bindings with multiple key proteins (AKT1, COX2 and Estrogen receptor 1) and competitively inhibits the activity of specific kinases. By binding to MELK to disrupt cell cycle regulation, Moracin G impairs the survival and proliferation of cancer cells, induces cancer cell apoptosis, and thereby exerts anti-tumor potential. Moracin G can be used in research related to periodontitis and breast cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 73338-86-0
- Formule: C19H16O4
- Masse moléculaire:308.33
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
|
Akt1 |
COX-2 |
Moracin G meets the pharmacokinetic criteria for active ingredients, with an oral bioavailability of 75.78% and a drug-likeness score of 0.42[1].
Moracin G is a key active component in mulberry leaves that alleviates periodontitis, and it interacts with 37 different human targets associated with periodontitis. The top 10 key targets are IL-6, ALB, TNF, VEGFA, AKT1, TP53, PTGS2, EGF, MMP9, and IL-10, among which the binding affinity with AKT1 is -10.7 kcal/mol[1].
Moracin G exhibits favorable in silico ADMET properties, including high gastrointestinal absorption, low blood-brain barrier permeability, and no predicted toxicity, rendering it a viable candidate for further development[2].
Moracin G is predicted to have a high probability of acting as a kinase inhibitor, antineoplastic agent, apoptosis agonist, and antineoplastic agent against breast cancer[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 73338-86-0
-
Masse moléculaire 308.33
-
Formule C19H16O4
-
SMILES
OC1=CC(O)=CC(C2=CC(C=CC3=C4CC=C(C)CO3)=C4O2)=C1
-
Structure Classification
-
Initial Source
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Wu Z, et al. Exploring the pharmacological components and effective mechanism of Mori Folium against periodontitis using network pharmacology and molecular docking. Arch Oral Biol. 2022;139:105391. [Content Brief]
[2]. Prasad P, et al. Computational identification of Moracin G and Isolonchocarpin as potent MELK inhibitors for anticancer drug discovery. Sci Rep. 2025;16(1):397. Published 2025 Dec 6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz