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Cat. No.: HY-114091A

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PF-00356231

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC₅₀=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC₅₀s of 0.00065, 1.7, 0.98, 0.39 μM, respectively.

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CAS No.: 766536-21-4
Formule: C₂₅H₂₀N₂O₃S
Masse moléculaire:428.50

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

PF-00356231 Chemical Structure

CAS No.: 766536-21-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

Voir tous les produits spécifiques à Isoform MMP :

In Vitro

PF-00356231 hydrochloride against MMP-12/13 can be affected significantly by the presence of acetohydroxamate (AH). PF-00356231 hydrochloride decreases the IC₅₀ values of MMP-12 (0.014 μM) and MMP-13 (0.27 μM) in the presence AH^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 766536-21-4
Masse moléculaire 428.50
Formule C₂₅H₂₀N₂O₃S
SMILES

OC(C[C@H](C1=CC=CC=C1)NC(C2=CC(C3=CC=C(C4=CC=NC=C4)C=C3)=CS2)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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JCI Insight

Targeting p300 and CBP abolishes HOXB13-loss-induced lipogenesis and tumor metastasis. [Abstract]

2025 Nov 24;10(22):e195743. PMID: 41277556
J Immunol Res

ADAM-10 Regulates MMP-12 during Lipopolysaccharide-Induced Inflammatory Response in Macrophages. [Abstract]

2022 Sep 16;2022:3012218. PMID: 36157882

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Morales R, et al. Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12. J Mol Biol. 2004 Aug 20;341(4):1063-76. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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PF-00356231

2 Cited Publications

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PF-00356231

Publications Citing Use of MedChemExpress (MCE) PF-00356231

Voir tous les produits spécifiques à Isoform MMP

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