Piperacillin hydrate
Based on 16 publication(s) in Google Scholar
Piperacillin hydrate is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin hydrate is most commonly used in combination with the β-lactamase inhibitor Tazobactam (HY-B1418).
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- CAS No.: 66258-76-2
- Formule: C23H29N5O8S
- Masse moléculaire:535.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Piperacillin hydrate
More- Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
- Nat Commun. 2022 Mar 2;13(1):1116. [Abstract]
- J Exp Med. 2026 Mar 2;223(3):e20241287. [Abstract]
- Virulence. 2026 Dec 31;17(1):2646808. [Abstract]
- Molecules. 2025 Mar 9;30(6):1224. [Abstract]
- Int J Antimicrob Agents. 2025 Oct;66(4):107551. [Abstract]
- PLoS Pathog. 2024 Dec 31;20(12):e1012783. [Abstract]
- Antimicrob Agents Chemother. 2023 Jun 15;67(6):e0160322. [Abstract]
- J Antimicrob Chemother. 2026 Feb 2;81(3):dkag034. [Abstract]
- J Antimicrob Chemother. 2025 Nov 5:dkaf408. [Abstract]
- Microbiol Spectr. 2023 Jun 15;11(3):e0069223. [Abstract]
- Microbiol Spectr. 2023 Feb 14;11(1):e0303822. [Abstract]
- Infect Drug Resist. 2026 May 8;19.
- Biomed Res Int. 2018 Jul 2:2018:3579832. [Abstract]
- medRxiv. 2025 Mar 13:2025.03.11.25323422. [Abstract]
- bioRxiv. 2024 May 10.
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Description
In Vitro
Piperacillin (12.5 μg/mL, 24h) hydrate inhibits 92% of isolates of Pseudomonas aeruginosa, 82% of Serratia marcescens, 73% of Escherichia coli, 61% of Klebsiella spp, and 42% of Enterobacter spp, most Proteus spp. are extremely susceptible. Piperacillin hydrate fails to inhibit the growth of gram-negative bacilli when large inocula were used (minimum inhibitory concentration >25 μg/mL) [2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c low inoculum model of K. pneumoniae, KEN-11 strain[3].
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Dosage:100 mg/kg
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Administration:Intravenous injection (i.v.), 4 times a day, 5 d, in combination with Tazobactam (12.5 mg/kg, i.v., 4 times a day, 5 d)
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Result:Enabled all mice survived whereas all control mice died by 5 d, decreased the number of bacteria in lungs compared with control group.
Observed no bacteria in the blood of most mice (except for two mice at the early phase) while bacteria were observed in the blood of control group.
Observed few inflammatory cells in the alveoli whereas an influx of numerous inflammatory cells were observed in the control group.
Chemical Information
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CAS No. 66258-76-2
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Masse moléculaire 535.57
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Formule C23H29N5O8S
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SMILES
O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC([C@H](NC(N3C(C(N(CC)CC3)=O)=O)=O)C4=CC=CC=C4)=O)N1C2=O)O.O
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Synonyms
Pipracil hydrate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (16)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Nat Commun
Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China. [Abstract]2022 Mar 2;13(1):1116. PMID: 35236849 -
J Exp Med
2026 Mar 2;223(3):e20241287. PMID: 41400657
Piperacillin hydrate purchased from MedChemExpress. Usage Cited in: J Exp Med. 2026 Mar 2;223(3):e20241287. [Abstract]
Piperacillin strongly inhibited microbial growth in riboflavin-synthesizing bacteria. Cecal and colonic microbiota from 2.5–3-week-old WT mice were anaerobically collected and cultured in Chopped Meat Carbohydrate Broth with the indicated antibiotics or no antibiotic (No Abx) for 24 hours at 37°C.
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Virulence
Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]2026 Dec 31;17(1):2646808. PMID: 41838520 -
Molecules
Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors. [Abstract]2025 Mar 9;30(6):1224. PMID: 40142001 -
Int J Antimicrob Agents
Elucidating adaptive compensatory tigecycline resistance mechanisms of RamA, RarA and SoxS in Klebsiella pneumoniae. [Abstract]2025 Oct;66(4):107551. PMID: 40499596 -
PLoS Pathog
Differential contribution of PBP occupancy and efflux on the effectiveness of β-lactams at their target site in clinical isolates of Neisseria gonorrhoeae. [Abstract]2024 Dec 31;20(12):e1012783. PMID: 39739989 -
Antimicrob Agents Chemother
Penicillin-Binding Protein 5/6 Acting as a Decoy Target in Pseudomonas aeruginosa Identified by Whole-Cell Receptor Binding and Quantitative Systems Pharmacology. [Abstract]2023 Jun 15;67(6):e0160322. PMID: 37199612 -
J Antimicrob Chemother
Comparative activity of established versus new-generation β-lactams against AmpC-hyperproducing clinical isolates of Enterobacter cloacae complex and Klebsiella aerogenes: a multicentre study. [Abstract]2026 Feb 2;81(3):dkag034. PMID: 41648989 -
J Antimicrob Chemother
Unravelling the triad of penicillin-binding proteins, β-lactamase activity, and mRNA dynamics in Pseudomonas aeruginosa AmpC induction. [Abstract]2025 Nov 5:dkaf408. PMID: 41206063 -
Microbiol Spectr
Penicillin-Binding Protein Occupancy Dataset for 18 β-Lactams and 4 β-Lactamase Inhibitors in Neisseria gonorrhoeae. [Abstract]2023 Jun 15;11(3):e0069223. PMID: 37093051 -
Microbiol Spectr
PBP Target Profiling by β-Lactam and β-Lactamase Inhibitors in Intact Pseudomonas aeruginosa: Effects of the Intrinsic and Acquired Resistance Determinants on the Periplasmic Drug Availability. [Abstract]2023 Feb 14;11(1):e0303822. PMID: 36475840 -
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Biomed Res Int
In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Mycobacterium tuberculosis Clinical Isolates. [Abstract]2018 Jul 2:2018:3579832. PMID: 30065936 -
medRxiv
The association between undetected heteroresistance and antibiotic treatment failure in complicated urinary tract infection. [Abstract]2025 Mar 13:2025.03.11.25323422. PMID: 40162257 -
Pureté et documentation
Références
[1]. Fu KP, et al. Piperacillin, a new penicillin active against many bacteria resistant to other penicillins. Antimicrob Agents Chemother. 1978, 13(3):358-67. [Content Brief]
[2]. Bodey GP, et al. Piperacillin: In Vitro Evaluation. Antimicrob Agents Chemother. 1978, 14(1):78-87. [Content Brief]
[3]. Harada Y, et al. In vitro and in vivo activities of piperacillin-tazobactam and meropenem at different inoculum sizes of ESBL-producing Klebsiella pneumoniae. Clin Microbiol Infect. 2014, 20(11):O831-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Piperacillin hydrate Related Classifications
HY-B1923A Related Classifications
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