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Cat. No.: HY-124364

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RO6889678

Name: RO6889678
Brand: MedChemExpress
SKU: HY-124364
Price: 230.00 USD
Availability: InStock
Rating: 5 (1 reviews)

RO6889678 is a highly potent HBV capsid formation inhibitor with a complex absorption, distribution, metabolism, and excretion (ADME) profile. RO6889678 is a potent inducer of CYP3A4 and coregulated proteins in human hepatocytes. RO6889678 is metabolized by a combination of CYP3A4-mediated oxidation and UDP-glucuronosyltransferase UGT1A3- and UGT1A1-mediated direct glucuronidation.

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CAS No.: 1578153-27-1
Formule: C₂₁H₂₀ClFN₄O₅S
Masse moléculaire:494.92

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

RO6889678 Chemical Structure

CAS No.: 1578153-27-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- Essai clinique
Chemical Information
Pureté et documentation
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Calculators
Help & FAQs
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Activité biologique

Description

IC₅₀ & Target^[1]

CYP3A4

Voir tous les produits spécifiques à Isoform Cytochrome P450 :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	>30 μM Compound: (R)-52	Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by manual-patch-clamp electrophysiology assay Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by manual-patch-clamp electrophysiology assay	[PMID: 29381358]
HepG2 2.2.15	EC₅₀	0.003 μM Compound: HAP_R10	Antiviral activity against HBV stably transfected in human HepG2.2.15 cells assessed as reduction of HBV DNA replication incubated for 5 days by q-PCR analysis Antiviral activity against HBV stably transfected in human HepG2.2.15 cells assessed as reduction of HBV DNA replication incubated for 5 days by q-PCR analysis	[PMID: 36896968]

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1578153-27-1
Masse moléculaire 494.92
Formule C₂₁H₂₀ClFN₄O₅S
SMILES

O=C([C@H]1N(CC2=C(C(OC)=O)[C@H](C3=CC=C(F)C=C3Cl)N=C(C4=NC=CS4)N2)CCOC1)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Nicole A Kratochwil, et al. Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor. J Pharmacol Exp Ther. 2018 May;365(2):237-248. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- Essai clinique
Chemical Information
Pureté et documentation
Références

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RO6889678

4,5-Dicaffeoylquinic acid

Morphothiadin

Bay 41-4109 racemate

AB-423

JNJ-632

4,5-Dicaffeoylquinic acid (Standard)

Bay 41-4109 racemate (Standard)

Morphothiadin (Standard)

Voir tous les produits spécifiques à Isoform Cytochrome P450

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Bioz

RO6889678

4,5-Dicaffeoylquinic acid

Morphothiadin

Bay 41-4109 racemate

AB-423

JNJ-632

4,5-Dicaffeoylquinic acid (Standard)

Bay 41-4109 racemate (Standard)

Morphothiadin (Standard)

Voir tous les produits spécifiques à Isoform Cytochrome P450

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

RO6889678 Related Classifications

HY-124364 Related Classifications

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