TP0628103
TP0628103 is a potent and highly selective MMP-7 inhibitor with an IC50 of 0.17 nM. TP0628103 undergoes structural optimization via molecular isoelectric point shifting, which reduces organic anion transporter (OAT)-mediated clearance, while maintaining potent MMP-7 inhibitory activity and enhancing MMP subtype selectivity. TP0628103 is applicable for research on the regulatory mechanisms of MMP-7-related matrix metalloproteinases.
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- CAS No.: 2865102-08-3
- Formule: C51H67ClF3N11O11S
- Masse moléculaire:1134.66
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
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MMP-7 0.17 nM (IC50) |
TP0628103 (compound 18) is a highly potent and selective human MMP-7 inhibitor, which exhibits only weak activity against human MMP-12 and MMP-14, and no significant activity against human MMP-1, MMP-2, MMP-3, MMP-8, MMP-9 or MMP-13. Moreover, it does not induce significant off-target effects at a concentration of 10 μM in human binding, enzymatic and uptake assays, or at a concentration of 1 μM in human absorption assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2865102-08-3
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Masse moléculaire 1134.66
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Formule C51H67ClF3N11O11S
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SMILES
CC(C)([C@@H](C(NC1=CC=C(C(N2CCC(C(N[C@@H](C(N3CC[C@@H](C3)N)=O)CCCCN)=O)CC2)=O)C=C1)=O)NC([C@@H](NC(CNC(CC[C@@H](C(O)=O)NS(=O)(C4=CC(C(F)(F)F)=C(Cl)C=C4)=O)=O)=O)CC5=CC=NC=C5)=O)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TP0628103 Related Classifications
HY-161169 Related Classifications
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