Triptriolide
Triptriolide inhibits Puromycin aminonucleoside PAN (HY-15695)-induced apoptosis in mouse podocytes through regulation of Bcl-2 family proteins and inhibition of Caspase-3. Triptriolide promotes the cell survival, protects and restores the podocyte function through activation of TAK1-NF-κB signaling pathway and upregulation of podocin.
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- CAS No.: 137131-18-1
- Formule: C20H26O7
- Masse moléculaire:378.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BGC-823 | IC50 |
>10 μM
Compound: 8d
|
Cytotoxicity against human BGC-823 cells by MTT assay
Cytotoxicity against human BGC-823 cells by MTT assay
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[PMID: 33289552] |
| HCT-116 | IC50 |
>10 μM
Compound: 8d
|
Cytotoxicity against human HCT-116 cells by MTT assay
Cytotoxicity against human HCT-116 cells by MTT assay
|
[PMID: 33289552] |
| HepG2 | IC50 |
>10 μM
Compound: 8d
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Cytotoxicity against human HepG2 cells by MTT assay
Cytotoxicity against human HepG2 cells by MTT assay
|
[PMID: 33289552] |
Chemical Information
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CAS No. 137131-18-1
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Masse moléculaire 378.42
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Formule C20H26O7
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SMILES
C[C@@]12[C@@]34[C@]5([C@@H]([C@@](O)([C@@H]([C@]3([H])O4)O)C(C)C)O)[C@@](C[C@@]1([H])C6=C(C(OC6)=O)CC2)([H])O5
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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