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Cat. No.: HY-P99201

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Biologically Validated

Zilovertamab

Name: Zilovertamab
Brand: MedChemExpress
SKU: HY-P99201
Price: 300.00 USD
Availability: InStock
Rating: 5 (2 reviews)

(Synonyms: UC-961; Cirmtuzumab)

2 Cited Publications

Avis client

Based on 2 publication(s) in Google Scholar

Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 98.21%
CAS No.: 2485779-13-1
Masse moléculaire:145.12 kDa

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Zilovertamab Chemical Structure

CAS No.: 2485779-13-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Essai clinique
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Publications (2)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling^[1].

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

Wnt5A

Voir tous les produits spécifiques à Isoform ROR :

Voir tous les produits spécifiques à Isoform Wnt :

In Vitro

Zilovertamab (25 and 50 μg/mL; 72 h) inhibits high-grade serous ovarian cancer (HGSOC) cell proliferation^[1].
Zilovertamab (50 μg/mL; 72 h) down-regulates ROR1 expression levels in CaOV3 at the transcriptional level^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

CaOV3, CaOV3CisR, PEO1, and PEO4 cells
Concentration:

25 and 50 µg/mL
Incubation Time:

72 hours
Result:

Reduced the proliferation of CaOV3, CaOV3CisR and PEO1.

Western Blot Analysis^[1]

Cell Line:

CaOV3, CaOV3CisR, PEO1, and PEO4 cells
Concentration:

50 µg/mL
Incubation Time:

72 hours
Result:

Down-regulated ROR1 expression levels in CaOV3 at the transcriptional level.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

4919 [NCBI]

Accession

Q01973

Target

ROR1

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG1 kappa

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized Human ROR1-ECD-His can bind Zilovertamab. The EC₅₀ for this effect is 3.078 ng/mL.

Chemical Information

CAS No. 2485779-13-1
Appearance Liquid
Masse moléculaire 145.12 kDa
Color Colorless to light yellow
SMILES

[Zilovertamab]
Synonyms

UC-961; Cirmtuzumab
Livraison

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Journal Impact Factor

Mol Ther

Development of a high-affinity anti-ROR1 variable region for broad anti-cancer immunotherapy. [Abstract]

2025 Dec 2:S1525-0016(25)00959-1. PMID: 41338184
Research Square Preprint

2024 Dec 02.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (260 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Références

[1]. Liu D, et, al. The Anti-ROR1 Monoclonal Antibody Zilovertamab Inhibits the Proliferation of Ovarian and Endometrial Cancer Cells. Pharmaceutics. 2022 Apr 11;14(4):837. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Zilovertamab

2 Cited Publications

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100 mg

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Activité biologique
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Essai clinique
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
- Biological Activity
Chemical Information
Publications (2)
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
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Pureté:
Quantité:

Zilovertamab

Publications Citing Use of MedChemExpress (MCE) Zilovertamab

Voir tous les produits spécifiques à Isoform ROR

Voir tous les produits spécifiques à Isoform Wnt