COX-2-IN-75
COX-2-IN-75 is an orally active and selective COX-2 inhibitor with an IC50 of 0.060 μM. COX-2-IN-75 reduces prostaglandin synthesis and inhibits NF-κB/IL-6 inflammatory signaling. COX-2-IN-75 attenuates paw edema in the formalin-induced rat paw edema model, demonstrating anti-inflammatory activity. COX-2-IN-75 can be used for research on inflammation-related diseases.
For research use only. We do not sell to patients.
- Formula: C26H19ClN6O
- Molecular Weight:466.92
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
COX-2 |
NF-κB |
IL-6 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Wistar (male, adult)[1]
-
Dosage:10 mg/kg
-
Administration:p.o. (gastric gavage); once daily; 7 consecutive days
-
Result:Produced stronger anti-edema efficacy than Indomethacin (HY-14397) and Celecoxib (HY-14398), and reduces NF-κB, COX-2, and IL-6 levels in paw tissue in formalin-induced paw edema in rats.
Chemical Information
-
Molecular Weight 466.92
-
Formula C26H19ClN6O
-
SMILES
O=C(C1=C2N=CC=C(C3=CC=C(Cl)C=C3)N2N=C1NC4=CC=CC=C4)N/N=C/C5=CC=CC=C5
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COX-2-IN-75 Related Classifications
HY-190644 Related Classifications
Powered by Bioz